t-Boc-Aminooxy-PEG2-CH2CO2H Chemical Properties

Density 

1.182±0.06 g/cm3(Predicted)

pka

3.39±0.10(Predicted)

t-Boc-Aminooxy-PEG2-CH2CO2H Usage And Synthesis

Description

t-Boc-Aminooxy-PEG2-CH2CO2H is a short PEG linker. The terminal carboxylic acid cis reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The Boc-protected amine can be deprotected under mild acidic conditions.

Uses

Boc-Aminooxy-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

t-Boc-Aminooxy-PEG2-CH2CO2H(2098983-14-1)Related Product Information

• Biotin-PEG36-PFP ester
• N-(Amino-PEG3)-N-bis(PEG4-Boc)
• BocNH-PEG5-acid
• Biotin-PEG6-t-butyl ester
• FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID
• 2-[2-[2-T-BOC-AMINOETHOXY]ETHOXY]ETHYL BROMIDE
• N-Boc-PEG4-bromide
• N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester)
• Mal-amido-PEG7-acid
• Fmoc-NH-PEG12-CH2COOH