N-Boc-PEG4-bromide Chemical Properties

Boiling point:

459.3±40.0 °C(Predicted)

Density 

1.223±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in DCM

pka

12.23±0.46(Predicted)

form 

Liquid

color 

Light yellow to brown

InChI

InChI=1S/C15H30BrNO6/c1-15(2,3)23-14(18)17-5-7-20-9-11-22-13-12-21-10-8-19-6-4-16/h4-13H2,1-3H3,(H,17,18)

InChIKey

KYOVSWOWVSWAII-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)NCCOCCOCCOCCOCCBr

N-Boc-PEG4-bromide Usage And Synthesis

Description

N-Boc-PEG4-bromide is a PEG linker containing a bromide group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Biological Activity

N-Boc-PEG5-bromide is a PROTAC linker that belongs to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

target

N-Boc-PEG4-bromide(1392499-32-9)Related Product Information

• 1,14-DIBROMO-3,6,9,12-TETRAOXATETRADECANE
• NA
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