N-Boc-PEG4-bromide
N-Boc-PEG4-bromide Basic information
- Product Name:
- N-Boc-PEG4-bromide
- Synonyms:
-
- N-Boc-PEG4-bromide
- BocNH-PEG4-CH2CH2Br
- N-Boc-PEG5-bromide
- Br-PEG4-NHBoc
- 5,8,11,14-Tetraoxa-2-azahexadecanoic acid, 16-bromo-, 1,1-dimethylethyl ester
- tert-butyl (14-bromo-3,6,9,12-tetraoxatetradecyl)carbamate
- ADC,antibody-drug,PROTAC Linkers,ADC Linkers,N-Boc-PEG-5-bromide,cleavable,inhibit,conjugates,Inhibitor,N Boc PEG5 bromide,NBocPEG5bromide,Antibody-drug conjugates linkers
- tert-butyl N-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate
- CAS:
- 1392499-32-9
- MF:
- C15H30BrNO6
- MW:
- 400.31
- Mol File:
- 1392499-32-9.mol
N-Boc-PEG4-bromide Chemical Properties
- Boiling point:
- 459.3±40.0 °C(Predicted)
- Density
- 1.223±0.06 g/cm3(Predicted)
- solubility
- Soluble in DCM
- pka
- 12.23±0.46(Predicted)
- form
- Liquid
- color
- Light yellow to brown
N-Boc-PEG4-bromide Usage And Synthesis
Description
N-Boc-PEG4-bromide is a PEG linker containing a bromide group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Biological Activity
N-Boc-PEG5-bromide is a PROTAC linker that belongs to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
| Alkyl/ether
|
N-Boc-PEG4-bromideSupplier
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- 0573-82087565 18966369783
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N-Boc-PEG4-bromide(1392499-32-9)Related Product Information
- 1,14-DIBROMO-3,6,9,12-TETRAOXATETRADECANE
- NA
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- 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol
- t-Boc-N-amido-PEG5-acid
- O-(2-AMINOETHYL)-O'-(2-(BOC-AMINO)ETHYL)
- N-Boc-PEG5-alcohol
- Biotin-PEG36-PFP ester
- N-(Amino-PEG3)-N-bis(PEG4-Boc)
- BocNH-PEG5-acid
- Biotin-PEG6-t-butyl ester
- FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID
- 2-[2-[2-T-BOC-AMINOETHOXY]ETHOXY]ETHYL BROMIDE
- t-Boc-Aminooxy-PEG2-CH2CO2H
- N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester)
- Mal-amido-PEG7-acid