N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester)
N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester) Basic information
- Product Name:
- N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester)
- Synonyms:
-
- N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester)
- N-(Amino-PEG4)-N-bis(PEG4-Boc)
- 4,7,10,13,19,22,25,28-Octaoxa-16-azahentriacontanedioic acid, 16-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-, 1,31-bis(1,1-dimethylethyl) ester
- HUN 53978
- Di-tert-butyl 16-(14-amino-3,6,9,12-tetraoxatetradecyl)-4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontanedioate
- N-(Amino-PEG4)-N-bis(PEG4-tert-butyl Ester)
- CAS:
- 2093153-97-8
- MF:
- C40H80N2O16
- MW:
- 845.07
- Mol File:
- 2093153-97-8.mol
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N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester) Chemical Properties
- Boiling point:
- 769.1±55.0 °C(Predicted)
- Density
- 1.079±0.06 g/cm3(Predicted)
- pka
- 8.74±0.10(Predicted)
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N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester) Usage And Synthesis
Description
N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester) is a branched PEG reagent containing an amino group with two t-butyl esters. The amino groups is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
N-(Amino-PEG4)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester)Supplier
Bide Pharmatech Ltd.
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