N-(Amino-PEG3)-N-bis(PEG4-Boc) Chemical Properties

Boiling point:

743.7±55.0 °C(Predicted)

Density 

1.076±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, protect from light

solubility 

Soluble in Water, DMSO, DCM, DMF

pka

8.74±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

N-(Amino-PEG3)-N-bis(PEG4-Boc) Usage And Synthesis

Description

N-(Amino-PEG3)-N-bis(PEG4-t-butyl ester) is a PEG linker that can easily react with activated NHS esters or carboxylic acid in the presence of EDC or HATU. The t-butyl group can be deprotected under acidic conditions.

Uses

N-(Amino-PEG3)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

N-(Amino-PEG3)-N-bis(PEG4-Boc)(2353409-57-9)Related Product Information

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