4-Pyridylmercapto acetyl chloride hydrochloride Chemical Properties

InChI

InChI=1S/C7H6ClNOS.ClH/c8-7(10)5-11-6-1-3-9-4-2-6;/h1-4H,5H2;1H

InChIKey

ONINFWNBKWMUCA-UHFFFAOYSA-N

SMILES

S(C1=CC=NC=C1)CC(=O)Cl.Cl

CAS DataBase Reference

27230-51-9(CAS DataBase Reference)

EPA Substance Registry System

Acetyl chloride, (4-pyridinylthio)-, hydrochloride (27230-51-9)

Safety Information

TSCA 

TSCA listed

4-Pyridylmercapto acetyl chloride hydrochloride Usage And Synthesis

Chemical Properties

White crystalline solid

Uses

4-Pyridylmercaptoacetyl Chloride is a reagent used in the synthesis of Cephalosporin (C258750) derivatives, used as an antibiotic.

Synthesis

4-Pyridylmercaptoacetic acid: 600-m1 of sodium hydroxide (88, 4, 9, 2, 21 mol) and water were placed in an EndPage:3 flask equipped with a condenser. 80-Mercaptoacetic acid (76, 79, 0, 67 mol) was added with stirring, followed by 4-chloropyridine hydrochloride (100 g, 0.67 mol). The mixture was heated under stirring at reflux temperature for 4 hours. About 5 g of cooled decolorized carbon was added to the resulting solution at 80??C. Stirring was continued for 5 min and then filtered using a filter aid. The r solution was acidified to pH 4.5 by the addition of acetic acid. the resulting slurry was cooled to 5 ??C and filtered to collect. 100 ml of solid! Wash Dissolve the wet filter cake in 6 NHC, 200 m,g and 500 ml of water. The clear solution was about 200 ml of 10% sodium hydroxide! Neutralize to pH 5. The slurry is cooled to 5??C, collected on a filter and washed with 200 ml of water. The solid was then washed with isopropanol 100rrLe. The product, 4-pyridylmercaptoacetic acid, was dried at 50 ??C at room temperature to give about 829 (73). Melting point 267-268??C (decomposition). Literature value: mp270°C.

4-Pyridylmercapto acetyl chloride hydrochloride(27230-51-9)Related Product Information

• Pyridine hydrochloride
• 6-Mercaptopurine
• Calcium thioglycolate
• Acetylacetone
• Acetyl chloride
• Polyvinyl chloride
• Ammonium chloride
• 2-Acetylpyridine
• Choline chloride
• 3-Acetylpyridine
• 4-Acetylpyridine
• Mercaptoacetic acid
• POTASSIUM THIOGLYCOLATE
• 3-Mercaptopropionic acid
• Sodium thioglycolate
• Topotecan hydrochloride
• Sodium chloride
• 2-Ethylhexyl mercaptoacetate