FMOC-Ala-OH Chemical Properties

Melting point:

147-153 °C (lit.)

alpha 

-19 º (c=1,DMF)

Boiling point:

451.38°C (rough estimate)

Density 

1.2626 (rough estimate)

refractive index 

-18.5 ° (C=1, DMF)

storage temp. 

Store below +30°C.

solubility 

DMSO (Slightly), DMF (Sparingly), Methanol (Slightly)

form 

Solid

pka

3.91±0.10(Predicted)

color 

White

optical activity

[α]20/D 18°, c = 1 in DMF

Water Solubility 

Soluble in water.

BRN 

2225975

InChIKey

QWXZOFZKSQXPDC-NSHDSACASA-N

CAS DataBase Reference

35661-39-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25-36/37/39-27-26

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29242990

MSDS

• Language:English Provider:FMOC-Ala-OH
• Language:English Provider:SigmaAldrich
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FMOC-Ala-OH Usage And Synthesis

Chemical Properties

white to light yellow crystal powde

Uses

FMOC-Ala-OH is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Alanine is one of the simplest amino acids - a methyl group as the side chain. This small side chain confers a high degree of flexibility when incorporated into a polypeptide chain. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group.

Preparation

A solution of the Fmoc-OX derivatives (20 mmol) in 100 mL acetone was added dropwise to a stirred solution of Alanine (20 mmol) and NaHCO₃ (50 mmol) in 100 mL water. After stirring overnight the reaction mixture was concentrated under reduced pressure and then extracted with CH₂Cl₂ (50 mL) to remove the unreacted Fmoc-OX derivatives. The reaction mixture was cooled and acidified with 10% HCl to congo red litmus paper to give a white solid, which was filtered and washed with water several times, dried to give a white solid (FMOC-Ala-OH).Yield=89.5%.

FMOC-Ala-OH(35661-39-3)Related Product Information

• FMOC-PHE-OH
• FMOC-ASP(OTBU)-OPFP
• Fmoc-Asp(OtBu)-OH
• Fmoc-Ile-OH
• FMOC-NLE-OH
• FMOC-GLN-OH
• Fmoc-Tyr(tBu)-OH
• Fmoc-Leu-OH
• FMOC-Ala-OH
• Fmoc-S-acetamidomethyl-L-cysteine
• FMOC-O-tert-Butyl-L-serine
• Fmoc-4-nitro-L-phenylalanine
• Fmoc-Lys(Boc)-OH
• FMOC-L-Valine
• Fmoc-Cys(tBu)-OH
• Nalpha-FMOC-L-Tryptophan
• Fmoc-Pro-OH
• Fmoc-L-Serine