Fmoc-Leu-OH
Fmoc-Leu-OH Basic information
- Product Name:
- Fmoc-Leu-OH
- Synonyms:
-
- FMOC-LEU-OH
- FMOC-L-LEU-OH
- FMOC-L-LEU
- FMOC-L-LEUCINE
- F-L-LEU
- Fmoc-L-leucine,98%
- L-Leucine-1-13C-N-FMOC
- Fmoc-N-(isobutyl)-glycine
- CAS:
- 35661-60-0
- MF:
- C21H23NO4
- MW:
- 353.41
- EINECS:
- 252-662-7
- Product Categories:
-
- Imidazoles ,Homopiperidines
- Leucine [Leu, L]
- Fmoc-Amino Acids and Derivatives
- Amino Acids (N-Protected)
- Biochemistry
- Fmoc-Amino Acids
- Protected Amino Acids
- Fluorenes, Flurenones
- AMINOACIDS DERIVATIVES
- Amino Acid Derivatives
- Amino Acids
- Fmoc-Amino acid series
- Prostanoid receptor and related
- 35661-60-0
- Mol File:
- 35661-60-0.mol
Fmoc-Leu-OH Chemical Properties
- Melting point:
- 152-156 °C(lit.)
- alpha
- -26 º (c=1,DMF 24 ºC)
- Boiling point:
- 486.83°C (rough estimate)
- Density
- 1.2107 (rough estimate)
- refractive index
- -25 ° (C=1, DMF)
- storage temp.
- Store below +30°C.
- solubility
- DMF (Slightly), DMSO (Slightly)
- form
- Solid
- pka
- 3.91±0.21(Predicted)
- color
- White to Off-White
- optical activity
- [α]20/D 25±2°, c = 1% in DMF
- BRN
- 2178254
- Stability:
- Hygroscopic
- InChIKey
- CBPJQFCAFFNICX-IBGZPJMESA-N
- CAS DataBase Reference
- 35661-60-0(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-36/37/39-27-26
- WGK Germany
- 3
- HS Code
- 2924 29 70
MSDS
- Language:English Provider:N-(9-Fluorenylmethoxycarbonyl)-L-leucine
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
Fmoc-Leu-OH Usage And Synthesis
Description
Fmoc-Leu-OH is isomeric with Fmoc-Ile-OH. Like isoleucine, leucine has branching in the sidechain. The branching is at the gamma carbon instead of the beta carbon as in isoleucine. It is used in chemical and peptide syntheses.
Chemical Properties
white to light yellow crystal powde
Uses
Fmoc-L-Leu-OH, is an amino acid derivative, used in peptide chemistry. It is also one of the novel PPARγ ligands that can activate PPARγ in different ways, that reduces osteoclasts differentiation, and thus are better therapeutic targets in diabetes than traditional antidiabetic drugs.
Application
Fmoc-Leu-OH can be used as a reactant to synthesize:
Various oligopeptides by reacting with functionalized α-amino acid hydrochloride salts.
A cyclic depsipeptide sansalvamide A, a natural product found in marine fungus.
Streptocidin A?D, decapeptide antibiotics naturally found in Streptomyces?sp. Tü 6071.
Coumaroyl dipeptide amide that can be used for cosmetic applications.
Preparation
Fmoc-L-leucine is prepared by reacting L-leucine with 9-fluorenylmethoxycarbonyl chloride.
Biological Activity
Anti-inflammatory agent; increases intracellular Ca 2+ levels. PPARγ ligand that induces insulin sensitization, but not adipogenesis.
Fmoc-Leu-OHSupplier
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Fmoc-Leu-OH(35661-60-0)Related Product Information
- L-Leucine
- N-(9-Fluorenylmethoxycarbonyloxy)succinimide
- N-CARBOBENZOXY-DL-LEUCINE
- L-tert-Leucine
- Glycine
- Fmoc-Aib-OH
- 9-Fluorenylmethyl chloroformate
- FMOC-Ala-OH
- Fmoc-Lys(Boc)-OH
- FMOC-N-METHYL-TRANEXAMIC ACID
- Fmoc-L-Tyr(propargyl)-OH
- Fmoc-Gly-OH
- FMOC-O-tert-Butyl-L-serine
- Fmoc-Asn(Trt)-OH
- FMOC-TRANEXAMIC ACID
- Nalpha-Fmoc-Ndelta-trityl-L-glutamine
- Fmoc-Tyr(tBu)-OH
- FMOC-METRP-OH