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Fmoc-Leu-OH

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Fmoc-Leu-OH Basic information

Product Name:
Fmoc-Leu-OH
Synonyms:
  • FMOC-LEU-OH
  • FMOC-L-LEU-OH
  • FMOC-L-LEU
  • FMOC-L-LEUCINE
  • F-L-LEU
  • Fmoc-L-leucine,98%
  • L-Leucine-1-13C-N-FMOC
  • Fmoc-N-(isobutyl)-glycine
CAS:
35661-60-0
MF:
C21H23NO4
MW:
353.41
EINECS:
252-662-7
Product Categories:
  • Imidazoles ,Homopiperidines
  • Leucine [Leu, L]
  • Fmoc-Amino Acids and Derivatives
  • Amino Acids (N-Protected)
  • Biochemistry
  • Fmoc-Amino Acids
  • Protected Amino Acids
  • Fluorenes, Flurenones
  • AMINOACIDS DERIVATIVES
  • Amino Acid Derivatives
  • Amino Acids
  • Fmoc-Amino acid series
  • Prostanoid receptor and related
  • 35661-60-0
Mol File:
35661-60-0.mol
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Fmoc-Leu-OH Chemical Properties

Melting point:
152-156 °C(lit.)
alpha 
-26 º (c=1,DMF 24 ºC)
Boiling point:
486.83°C (rough estimate)
Density 
1.2107 (rough estimate)
refractive index 
-25 ° (C=1, DMF)
storage temp. 
Store below +30°C.
solubility 
DMF (Slightly), DMSO (Slightly)
form 
Solid
pka
3.91±0.21(Predicted)
color 
White to Off-White
optical activity
[α]20/D 25±2°, c = 1% in DMF
BRN 
2178254
Stability:
Hygroscopic
InChIKey
CBPJQFCAFFNICX-IBGZPJMESA-N
CAS DataBase Reference
35661-60-0(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36/37/39-27-26
WGK Germany 
3
HS Code 
2924 29 70

MSDS

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Fmoc-Leu-OH Usage And Synthesis

Description

Fmoc-Leu-OH is isomeric with Fmoc-Ile-OH. Like isoleucine, leucine has branching in the sidechain. The branching is at the gamma carbon instead of the beta carbon as in isoleucine. It is used in chemical and peptide syntheses.

Chemical Properties

white to light yellow crystal powde

Uses

Fmoc-L-Leu-OH, is an amino acid derivative, used in peptide chemistry. It is also one of the novel PPARγ ligands that can activate PPARγ in different ways, that reduces osteoclasts differentiation, and thus are better therapeutic targets in diabetes than traditional antidiabetic drugs.

Application

Fmoc-Leu-OH can be used as a reactant to synthesize:
Various oligopeptides by reacting with functionalized α-amino acid hydrochloride salts.
A cyclic depsipeptide sansalvamide A, a natural product found in marine fungus.
Streptocidin A?D, decapeptide antibiotics naturally found in Streptomyces?sp. Tü 6071.
Coumaroyl dipeptide amide that can be used for cosmetic applications.

Preparation

Fmoc-L-leucine is prepared by reacting L-leucine with 9-fluorenylmethoxycarbonyl chloride.

Biological Activity

Anti-inflammatory agent; increases intracellular Ca 2+ levels. PPARγ ligand that induces insulin sensitization, but not adipogenesis.

Fmoc-Leu-OHSupplier

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