Fmoc-Gly-OH Chemical Properties

Melting point:

174-175 °C(lit.)

Boiling point:

438.82°C (rough estimate)

Density 

1.1671 (rough estimate)

refractive index 

1.4500 (estimate)

storage temp. 

2-8°C

solubility 

almost transparency in Methanol

form 

Powder

pka

3.89±0.10(Predicted)

color 

White

BRN 

2163967

InChI

InChI=1S/C17H15NO4/c19-16(20)9-18-17(21)22-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15/h1-8,15H,9-10H2,(H,18,21)(H,19,20)

InChIKey

NDKDFTQNXLHCGO-UHFFFAOYSA-N

SMILES

C(O)(=O)CNC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

CAS DataBase Reference

29022-11-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25-36-26

WGK Germany 

3

HS Code 

29242995

MSDS

• Language:English Provider:Fmoc-Gly-OH
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Fmoc-Gly-OH Usage And Synthesis

Chemical Properties

white to light yellow crystal powde

Uses

Fmoc-Gly-OH is an N-Fmoc-protected form of Glycine (G615990). Glycine is a nonessential amino acid that acts as an inhibitory neyrotransmitter in the vertebrate central nervous system. Glycine also posesses cytoprotective against oxidant damage in the kidney.

Preparation

Glycine (Gly) (0.5 g, 6.66 mmol) was dissolved in 10% NaCO₃ (14 ml) under stirring in a 50-ml flask. To the resulting solution, which had been put into an ice bath, 9-fluorenylmethoxycarbonyl chloride (Fmoc-Cl) (1.72 g, 6.66 mmol) in dioxane (12 ml) was gradually added. The reaction mixture was stirred at room temperature for 4 hours. Then added water (150 ml) to the mixture. The aqueous phase layer was separated from the reaction mixture and stripped with ether three times (75 ml×3). The stripped aqueous layer was acidified with 2N HCl aqueous solution to a pH=2, followed by extraction with ethyl acetate three times (75 ml×3). The organic phase layer was recovered and concentrated to obtain crude product of 1.70 g. The crude product was recrystallized in a mixed solvent of ethyl acetate hexane=1:2 (30 ml), and white solid denoted as Fmoc-Gly-OH was obtained after filtration at a reduced pressure.

General Description

The product number for this product was previously 04-12-1001.

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Fmoc-Gly-OH(29022-11-5)Related Product Information

• 9-Fluorenylmethyl chloroformate
• 4-Aminophenylacetic acid
• N-Carbobenzyloxyglycine
• 4-Hydroxy-D-(-)-2-phenylglycine
• Glycine
• N-(9-Fluorenylmethoxycarbonyloxy)succinimide
• Fmoc-Aib-OH
• FMOC-O-tert-Butyl-L-serine
• Fmoc-Lys(Boc)-OH
• Fmoc-Leu-OH
• Fmoc-Tyr(tBu)-OH
• FMOC-AMINOXYACETIC ACID
• Fmoc-L-Serine
• 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-butanoic acid
• FMOC-N-METHYL-TRANEXAMIC ACID
• Fmoc-L-Tyr(propargyl)-OH
• Fmoc-Asn(Trt)-OH
• FMOC-TRANEXAMIC ACID