Basic information Safety Supplier Related

Azido-PEG7-COOtBu

Basic information Safety Supplier Related

Azido-PEG7-COOtBu Basic information

Product Name:
Azido-PEG7-COOtBu
Synonyms:
  • Azido-PEG7-COOtBu
  • Azido-PEG7-tBu Ester
  • N3-PEG7-COOtBu
CAS:
2596867-40-0
MW:
0
Mol File:
Mol File
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Azido-PEG7-COOtBu Usage And Synthesis

Biological Activity

Azido-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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