Azido-PEG7-COOtBu
Azido-PEG7-COOtBu Basic information
- Product Name:
- Azido-PEG7-COOtBu
- Synonyms:
-
- Azido-PEG7-COOtBu
- Azido-PEG7-tBu Ester
- N3-PEG7-COOtBu
- CAS:
- 2596867-40-0
- MW:
- 0
- Mol File:
- Mol File
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Azido-PEG7-COOtBu Usage And Synthesis
Biological Activity
Azido-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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