1-Azido-23-bromo-3,6,9,12,15,18,21-heptaoxatricosane Chemical Properties

storage temp. 

2-8°C, sealed storage, away from moisture

form 

Liquid

color 

Colorless to light yellow

1-Azido-23-bromo-3,6,9,12,15,18,21-heptaoxatricosane Usage And Synthesis

Uses

Bromo-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromo-PEG7-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Biological Activity

Bromo-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

1-Azido-23-bromo-3,6,9,12,15,18,21-heptaoxatricosane(1056969-61-9)Related Product Information

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• Azido-PEG7-hydrazide
• Azido-PEG7-azide
• Azido-PEG7-COOtBu
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