1-Azido-23-bromo-3,6,9,12,15,18,21-heptaoxatricosane
1-Azido-23-bromo-3,6,9,12,15,18,21-heptaoxatricosane Basic information
- Product Name:
- 1-Azido-23-bromo-3,6,9,12,15,18,21-heptaoxatricosane
- Synonyms:
-
- 1-Azido-23-bromo-3,6,9,12,15,18,21-heptaoxatricosane
- N3-PEG7-CH2CH2Br
- N3-PEG7-CH2CH2Br/3,6,9,12,15,18,21-Heptaoxatricosane, 1-azido-23-bromo-
- CAS:
- 1056969-61-9
- MF:
- C16H32BrN3O7
- MW:
- 458.35
- Mol File:
- 1056969-61-9.mol
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1-Azido-23-bromo-3,6,9,12,15,18,21-heptaoxatricosane Usage And Synthesis
Biological Activity
Bromo-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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