N3-PEG7-OH Chemical Properties

storage temp. 

Store at Room Tem.

solubility 

Soluble in Water, DMSO, DCM, DMF

InChI

InChI=1S/C14H29N3O7/c15-17-16-1-3-19-5-7-21-9-11-23-13-14-24-12-10-22-8-6-20-4-2-18/h18H,1-14H2

InChIKey

IKLKCSJOBKMTTI-UHFFFAOYSA-N

SMILES

C(COCCOCCOCCO)OCCOCCOCCN=[N+]=[N-]

N3-PEG7-OH Usage And Synthesis

Description

Azido-PEG7-alcohol is a aqueous soluble PEGylation reagent The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Hydroxy group further increase the reagnt's water solubility.

Uses

Azido-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG7-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

N3-PEG7-OH(1274892-60-2)Related Product Information

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• Azido-PEG7-hydrazide
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• Azido-PEG12-NHS ester
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• Azido-PEG5-acid
• Azido-PEG1-acid