4-Chloro-6-methoxypyrimidine Chemical Properties

Melting point:

34.5-35.0 °C

Boiling point:

80°C/18mmHg(lit.)

Density 

1.292±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to lump to clear liquid

pka

-1.59±0.17(Predicted)

color 

White or Colorless to Light yellow

InChI

InChI=1S/C5H5ClN2O/c1-9-5-2-4(6)7-3-8-5/h2-3H,1H3

InChIKey

KLJGSQVYUGQOAW-UHFFFAOYSA-N

SMILES

C1=NC(OC)=CC(Cl)=N1

CAS DataBase Reference

26452-81-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

41

Safety Statements 

26-39

HS Code 

29335990

4-Chloro-6-methoxypyrimidine Usage And Synthesis

Uses

4-Chloro-6-methoxypyrimidine could be the starting material for preparing 4-chloro-6-hydroxypyrimidine.

Synthesis

A) Methanol (5.4 mL) was slowly added dropwise to a suspension of tetrahydrofuran (THF, 200 mL) containing 60% sodium hydride (8.05 g) under nitrogen protection, keeping the reaction temperature at 0 °C. Subsequently, a solution of 4,6-dichloropyrimidine (20.0 g) in THF (45 mL) was added to the reaction system at 0 °C, and the reaction continued to be stirred at 0 °C for 1 hour. Upon completion of the reaction, 1N hydrochloric acid was slowly added to the reaction mixture at 0 °C for neutralization, followed by extraction of the reaction product with ethyl acetate. The organic phase was washed sequentially with water and saturated brine and dried with anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the residue was recrystallized by hexane to afford the target product 4-chloro-6-methoxypyrimidine (10.2 g) as light yellow crystals. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 3.96 (3H, s), 7.19 (1H, s), 8.69 (1H, s).

References

[1] Tetrahedron Letters, 2005, vol. 46, # 23, p. 3977 - 3979
[2] European Journal of Medicinal Chemistry, 2005, vol. 40, # 9, p. 862 - 874
[3] Patent: US2013/143870, 2013, A1. Location in patent: Paragraph 0267; 0268; 0269
[4] Patent: US2013/137688, 2013, A1. Location in patent: Paragraph 0221; 0222; 0223; 0224
[5] Patent: US2013/158038, 2013, A1. Location in patent: Paragraph 0134; 0135

4-Chloro-6-methoxypyrimidine(26452-81-3)Related Product Information

• m-Anisyl alcohol
• Anisole
• (Trifluoromethoxy)benzene
• p-Anisidine
• Epichlorohydrin
• 4-Methoxybenzylchloride
• Methoxyacetic acid
• 4-CHLORO-6-METHOXYQUINOLINE
• Difluorochloromethane
• 4-chloro-6-methoxy-2-methylpyrimidin-5-amine
• 2-AMINO-4-CHLORO-6-ETHOXYPYRIMIDINE
• 6-CHLORO-2,4-DIMETHOXYPYRIMIDINE
• 2,4-Dichloro-6-methoxypyrimidine
• 2-Amino-4-chloro-6-methoxypyrimidine
• 4-BENZYLOXY-6-CHLOROPYRIMIDINE
• Moxonidine
• 1-[2-(Ethoxycarbonyl)phenylsulfonyl]-3-(4-chloro-6-methoxypyrimidine-2-yl)urea
• Chloroacetic acid