2-Nitrobenzeneboronic acid pinacol ester Chemical Properties

Melting point:

42-44°C

Boiling point:

358.2±25.0 °C(Predicted)

Density 

1.14±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

color 

White to Orange to Green

BRN 

7708824

CAS DataBase Reference

190788-59-1(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36

HS Code 

2931900090

MSDS

• Language:English Provider:ALFA

2-Nitrobenzeneboronic acid pinacol ester Usage And Synthesis

Synthesis

1-Bromo-2-nitrobenzene (10.0 g, 49.5 mmol, 1.0 eq.) and pinacol ester of bis(diphenylphosphine) (15.08 g, 59.4 mmol, 1.2 eq.) were added with potassium acetate (14.57 g, 148 mmol, 3.0 eq.) and [1,1'-bis(diphenylphosphino)palladium(II) dichloride] (1.09 g, 1.49 mmol, 0.03 equiv) in dioxane (180 mL). The reaction mixture was stirred at 80 °C for 12 hours under nitrogen protection. After completion of the reaction, the mixture was concentrated under reduced pressure to give the crude product. Purification by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, 100:1 to 80:1) afforded 2-nitrophenylboronic acid pinacol ester as a yellow oil (12.0 g, 97% yield). The product was identified by 1H NMR (DMSO-d6, 400 MHz): δ 8.17 (d, J = 8.0 Hz, 1H), 7.67-7.65 (m, 1H), 7.58-7.54 (m, 2H), 1.44 (s, 12H).

References

[1] Patent: WO2018/144620, 2018, A1. Location in patent: Paragraph 00334
[2] Advanced Synthesis and Catalysis, 2016, vol. 358, # 6, p. 977 - 983
[3] Synlett, 2018, vol. 29, # 8, p. 1055 - 1060
[4] Journal of the American Chemical Society, 2015, vol. 137, # 21, p. 6738 - 6741
[5] Patent: CN108424344, 2018, A. Location in patent: Paragraph 0083; 0084; 0085; 0095

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