2-Chloroethyl chloroformate Chemical Properties

Melting point:

<25 °C

Boiling point:

155-156°C

Density 

1.385

vapor pressure 

0.23 psi ( 20 °C)

refractive index 

1.446

Flash point:

158°F

storage temp. 

Inert atmosphere,2-8°C

solubility 

soluble in Ether,Benzene,Acetone

form 

Liquid

color 

Colorless to yellow

BRN 

506639

InChIKey

SVDDJQGVOFZBNX-UHFFFAOYSA-N

CAS DataBase Reference

627-11-2(CAS DataBase Reference)

NIST Chemistry Reference

Carbonochloridic acid, 2-chloroethyl ester(627-11-2)

EPA Substance Registry System

2-Chloroethyl chloroformate (627-11-2)

Safety Information

Hazard Codes 

T

Risk Statements 

23-34

Safety Statements 

26-36/37/39-45

RIDADR 

3277

WGK Germany 

3

RTECS 

LQ5950000

HazardClass 

6.1(a)

PackingGroup 

II

HS Code 

29159000

Hazardous Substances Data

627-11-2(Hazardous Substances Data)

MSDS

• Language:English Provider:2-Chloroethyl chloroformate

2-Chloroethyl chloroformate Usage And Synthesis

Chemical Properties

Clear colorless liquid

Uses

2-Chloroethyl Chloroformate is a reactant used in the preparation of artemisinin-derived dimer carbonates and thiocarbonates with antimalarial activity.

General Description

Liquid.

Air & Water Reactions

Decomposed slowly by water forming ethanol, HCl, and CO2; on contact with moist air, 2-Chloroethyl chloroformate gives off HCl fumes; attacks many metals especially in humid atmosphere. REF [Handling Chemicals Safely, 1980. p. 476].

Reactivity Profile

2-Chloroethyl chloroformate is an acid halide. Acid halides are water reactive; some are violently reactive. They are incompatible with strong oxidizing agents, alcohols, amines, alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

(Non-Specific -- Ethyl Chloroformate) Poisonous; may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes.

Safety Profile

Poison by inhalation. May also cause fatahties by ingestion or skin contact. May cause burns to the eyes and skin. When heated to decomposition it emits toxic fumes of Cl-

Purification Methods

Purify it by fractional distillation, preferably in a vacuum and store it in a dry atmosphere. [Jones J Chem Soc 2735 1957, Beilstein 3 IV 24.]

2-Chloroethyl chloroformate(627-11-2)Related Product Information

• Triethylamine
• Dimethyl carbonate
• Diethyl malonate
• Pivalic acid
• Tripropyl orthoformate
• 2-Chlorobenzoic acid
• Benzyl chloroformate
• Diphosgene
• Isobutyl chloroformate
• Isopropyl chloroformate
• HEXYL CHLOROFORMATE
• Allyl chloroformate
• Cyclopentyl chloroformate
• Pentyl chloroformate
• Cyclohexyl chloroformate
• ChloroMethyl Methyl Carbonate
• 9-Fluorenylmethyl chloroformate
• 4-Nitrobenzyl chloroformate