DEMETHOXYCURCUMIN Chemical Properties

Melting point:

166～170℃

Boiling point:

571.4±50.0 °C(Predicted)

Density 

1.282±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: ≥10mg/mL

form 

powder

pka

8.31±0.46(Predicted)

color 

orange

LogP

3.113 (est)

Safety Information

Hazard Codes 

N

Risk Statements 

50

Safety Statements 

61

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

2

HS Code 

29145090

DEMETHOXYCURCUMIN Usage And Synthesis

Uses

The demethoxy derivative of Curcumin (C838500) that regulates anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. It attenuates the Wnt/β-catenin pathway through do wn-regulation of the transcriptional coactivator p300.

Uses

Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 μM. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS.

Definition

ChEBI: Demethoxycurcumin is a beta-diketone that is curcumin in which one of the methoxy groups is replaced by hydrogen. It is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent. It is a polyphenol, a beta-diketone, an enone and a diarylheptanoid.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Demethoxycurcumin (DMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. DMC inhibits LPS-induced nitric oxide (NO) production, and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. DMC also inhibits NF-kB dependent iNOS, TNFα and IL-1β expression in LPS-treated rat microglial cells. DMC suppresses expression of MMPs and ICAM-1 in MDA-MB-231 human breast cancer cells by inhibition of NF-kB.

DEMETHOXYCURCUMIN(22608-11-3)Related Product Information

• Tetrahydrocurcumin
• 5"-MethoxyhexahydrocurcuMin
• BIS(4-HYDROXYCINNAMOYL)METHANE
• (3S,5S)-1,7-BIS(4-HYDROXY-3-METHOXYPHENYL)HEPTANE-3,5-DIOL
• DihydrocurcuMin
• ASC-J9
• HEXAHYDROCURCUMIN
• FLLL31
• lithospermic acid
• 13,14-Didehydromatridin-15-one
• Curcumin
• BIS(4-HYDROXYCINNAMOYL)METHANE
• DEMETHOXYCURCUMIN
• CURCUMIN, [3H]-
• CURCUMIN DIACETATE