5-Methyltryptamine hydrochloride Chemical Properties

Melting point:

290-292 °C

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

Pale Beige to Light Tan

Sensitive 

Hygroscopic

CAS DataBase Reference

1010-95-3

Safety Information

Hazard Codes 

T+

Risk Statements 

26/27/28

Safety Statements 

22-24/25

RIDADR 

2811

WGK Germany 

3

F 

10

HazardClass 

6.1

PackingGroup 

Ⅲ

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

5-Methyltryptamine hydrochloride Usage And Synthesis

Chemical Properties

Light Tan Solid

Uses

• reactant in synthesis of kinesin spindle protein (KSP) inhibitors
• reactant in intramolecular furan Diels-Alder reactions
• reactant in Pictet-Spengler-like reactions

Uses

5-Methyltryptamine hydrochloride is a methylated derivative of tryptamine, it is a weak antagonist of 5-Hydroxytryptamine (H974990) with weak potency as stimulants of the cardiac sympathetic nerves. 5-Methyltryptamine hydrochloride is also used in the preparation of inhibitors of kinesin spindle protein (KSP), a promising class of anticancer agents.

Purification Methods

Recrystallise the hydrochloride from H2O. The free base has m 96-98o (from *C6H6/cyclohexane) or m 99-100o (from pet ether), and the picrate has m 243o(dec) (from EtOH). [Young J Chem Soc 3493 1958, Gaddum et al. Quart J Exp Physiol 40 49 1955, R.hm Hoppe Seyler's Z Physiol Chem 297 229 1954, Beilstein 22 III/IV 4364, 22/10 V 167.]

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