Isobutyrophenone Chemical Properties

Melting point:

1 °C

Boiling point:

217 °C (lit.)

Density 

0.988 g/mL at 25 °C (lit.)

vapor pressure 

1 mm Hg ( 50 °C)

refractive index 

n20/D 1.517(lit.)

Flash point:

184 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Sparingly), Methanol (Slightly)

form 

Oil

color 

Colourless

Water Solubility 

immiscible

BRN 

774499

LogP

2.73

CAS DataBase Reference

611-70-1(CAS DataBase Reference)

NIST Chemistry Reference

Isopropyl phenyl ketone(611-70-1)

EPA Substance Registry System

1-Propanone, 2-methyl-1-phenyl- (611-70-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

TSCA 

Yes

HS Code 

29143900

MSDS

• Language:English Provider:2-Methyl-1-phenyl-1-propanone
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Isobutyrophenone Usage And Synthesis

Chemical Properties

clear colorless to very slightly yellow liquid

Uses

Isobutyrophenone is used as an internal standard in the determination of hydroxyzine hydrochloride and benzyl alcohol in injection solutions. It is also used in the preparation of alpha-hydroxyisobutyrophenone. Isobutyrophenone is employed as photosensitizer intermediate. It can react with bromoacetic acid ethyl ester to get 3-hydroxy-4-methyl-3-phenyl-valeric acid ethyl ester.

Preparation

Isobutyrophenone synthesis: Benzene underwent a Friedel–Crafts acylation with isobutyryl chloride to synthesize isobutyrophenone. The reaction was performed using excess benzene as a replacement for a typical solvent and heat to reflux (88 °C) for a period of 3 hours. Any unreacted benzene was recovered after the reaction during the distillation process. A 66 % yield of isobutyrophenone was obtained from the solar synthesis, compared to a 44 % yield from an in-lab, electrical heating analysis.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 1061, 1949 DOI: 10.1021/ja01171a084
The Journal of Organic Chemistry, 32, p. 404, 1967 DOI: 10.1021/jo01288a032
Tetrahedron Letters, 14, p. 2491, 1973

Flammability and Explosibility

Non flammable

Isobutyrophenone(611-70-1)Related Product Information

• Benzoyl peroxide
• Methylparaben
• 3-Methyl-2-butanone
• PHENYL VALERATE
• N-Methyl-2-pyrrolidone
• Cumene
• Butyrophenone
• 1,5-Diphenylcarbazide
• O-Phthalimide
• Kresoxim-methyl
• Methyl acrylate
• Benzoylmetronildazole
• 4-Methoxyphenylacetone
• N,N-Diisopropylethylamine
• Thiophanate-methyl
• Citric acid monohydrate
• Cyclopropyl methyl ketone
• Methyl isobutyrylacetate