SB 204741 Chemical Properties

Melting point:

>195°C (dec.)

storage temp. 

2-8°C

solubility 

DMSO: ~18 mg/mL, soluble

form 

solid

color 

orange

Stability:

Hygroscopic

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

SB 204741 Usage And Synthesis

Uses

SB 204741 is a potent, selective SR-2B antagonist.

Definition

ChEBI: 1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea is a member of ther class of ureas that is urea in which a hydrogen attached to one of the nitrogens has been replaced by an N-methylindol-5-yl group, while a hydrogen attached to the other nitrogen has been replaced by a 3-methyl-1,2-thiazol-5-yl group. It is a potent and selective antagonist for the 5-hydroxytryptamine 2B (5-HT2B) receptor. It has a role as a receptor modulator and a serotonergic antagonist. It is a member of ureas, a member of indoles and a member of 1,2-thiazoles.

Biological Activity

Potent and selective 5-HT 2B receptor antagonist (pA 2 = 7.95). Displays ≥ 135-fold selectivity over 5-HT 2C (pK i = 5.82), 5-HT 2A (pK i < 5.2), 5-HT 1A , 1D , 1E , 5-HT 3 and 5-HT 4 receptors.

storage

Room temperature

SB 204741(152239-46-8)Related Product Information

• Sb-742457
• SBI-0206965
• SB9200
• GSK-CXCR2
• SBI-993
• SB-649868
• SB1317
• SB 203580
• SB1317
• 5-AMINO-3-METHYLISOTHIAZOLE HYDROCHLORIDE
• SB 204741
• 3-METHYLISOTHIAZOLE
• 5-AMINO-1-N-METHYLINDOLE