(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE
(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Basic information
- Product Name:
- (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE
- Synonyms:
-
- SB 328437
- (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE
- SB 328437 - CAS 247580-43-4 - Calbiochem
- N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalaninemethylester
- Methyl (2S)-2-(1-naphthoylaMino)-3-(4-nitrophenyl)propanoate
- L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester
- SB 328437 >=98% (HPLC)
- Methyl (S)-2-(1-naphthamido)-3-(4-nitrophenyl)propanoate
- CAS:
- 247580-43-4
- MF:
- C21H18N2O5
- MW:
- 378.38
- Mol File:
- Mol File
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(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Chemical Properties
- Boiling point:
- 642.9±50.0 °C(Predicted)
- Density
- 1.305±0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- DMSO: ≥10mg/mL
- pka
- 12.51±0.46(Predicted)
- form
- White solid
- color
- white to tan
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(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Usage And Synthesis
Uses
SB 328437 is a potent and selective CCR3 receptor antagonist.
Biological Activity
SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. It suppresses the Th2-mediated eosinophil infiltration in the airways.', 'SB-328437 is a potent, selective CCR-3 antagonist (IC50 = 1.6 nM). The compound blockes CCR3 agonist-induced calcium mobilization in CCR3 expressing cells with the following IC50 values: eotaxin, 38 nM; eotaxin-2, 35 nM and MCP4, 20 nM.
in vivo
SB-328437 (intraperitoneal injection; 5 g/kg; single dose) has a beneficial effect in mouse models of LPS (HY-D1056)-induced lung injury and influenza virus infection[2].
| Animal Model: | Influenza A strain pmd09 treated C57BL/6 female mice aged 8-10 weeks old (18-20 g) [2] |
| Dosage: | 5 g/kg |
| Administration: | Intraperitoneal injection (i.p.); single dose |
| Result: | Reduced neutrophil recruitment to the lung alveolar space. Reduced tissue damage. Reduced lung inflammation and the expression of pro-inflammatory cytokines, Tnfa and Cxcl1. Decreased the activation level of neutrophils. Lowered the viral load in mice. |
IC 50
CCR3: 4.5 nM (IC50)
storage
Store at +4°C
(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATESupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
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- 821-50328103-801 18930552037
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Guangzhou Isun Pharmaceutical Co., Ltd
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- 020-39119399 18927568969
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EMMX Biotechnology LLC
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- 888-539-0666
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Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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Tianjin Kailiqi Biotechnology Co., Ltd.
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- 15076683720
- klq@cw-bio.com