SB 200646 HYDROCHLORIDE
SB 200646 HYDROCHLORIDE Basic information
- Product Name:
- SB 200646 HYDROCHLORIDE
- Synonyms:
-
- SB 200646
- SB 200646 HYDROCHLORIDE
- N-(1-METHYL-1H-5-INDOLYL)-N'-(3-PYRIDINYL)UREA HYDROCHLORIDE
- N-(1-METHYL-1H-INDOL-5-YL)-N'-3-PYRIDINYLUREA HYDROCHLORIDE
- SB200646HCl
- N-(1-methyl-5-indolyl)-N'-(3-pyridyl)urea
- N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea
- 1-(1-Methyl-1H-indol-5-yl)-3-pyridin-3-yl-urea
- CAS:
- 143797-63-1
- MF:
- C15H14N4O
- MW:
- 266.3
- Mol File:
- 143797-63-1.mol
SB 200646 HYDROCHLORIDE Chemical Properties
- storage temp.
- 2-8°C
- solubility
- DMSO: ~26 mg/mL, soluble
- form
- solid
- color
- pale yellow
- Water Solubility
- Water: 1 mg/mL (NaN mM)
MSDS
- Language:English Provider:SigmaAldrich
SB 200646 HYDROCHLORIDE Usage And Synthesis
Uses
SB 200646 Hydrochloride is a 5-HT2C antagonist.
Definition
ChEBI: SB 200646 is a member of indoles.
Biological Activity
5-HT 2C/2B receptor antagonist, selective over 5-HT 1A . Affinities are 7.4 (pA 2 ), 6.9 (pK i ) and 5.2 (pK i ) for 5-HT 2B , 2C and 2A respectively. Orally active in vivo .
in vivo
SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons[1].
The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons[1].
| Animal Model: | Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment)[1] |
| Dosage: | 20 mg/kg |
| Administration: | Intravenous injection; daily; for 21 days |
| Result: | Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons. |
IC 50
5-HT2B Receptor: 7.5 (pKi); 5-HT2C Receptor: 6.9 (pKi); 5-HT2A Receptor: 5.2 (pKi)
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