m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate CAS#: 882366-16-7

m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate Basic information

Product Name:

m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate

Synonyms:

m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate
SBI 115
SBI115
SBI-115
SBI-115; SBI 115; SBI115
4-Pyrimidinecarboxylic acid, 5-chloro-2-(ethylsulfonyl)-, 3-methylphenyl ester
3-Methylphenyl 5-chloro-2-(ethylsulfonyl)-4-pyrimidinecarboxylate
G protein-coupled Bile Acid Receptor 1,GPCR19,TGR5,SBI115,GPBAR1,Inhibitor,SBI-115,SBI 115,G-protein coupled receptor 19,inhibit

CAS:

882366-16-7

MF:

C14H13ClN2O4S

MW:

340.78

Mol File:

882366-16-7.mol

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m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate Chemical Properties

Boiling point:: 529.7±60.0 °C(Predicted)
Density: 1.386±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO:109.0(Max Conc. mg/mL);319.86(Max Conc. mM)
pka: -7.73±0.49(Predicted)
form: Solid
color: White to off-white

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m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate Usage And Synthesis

Uses

SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5[1].

References

[1] Masyuk TV, et al. TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling. Hepatology. 2017 Oct; 66(4):1197-1218. DOI:10.1002/hep.29284

m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylateSupplier

Nanjing Chemlin Chemical Co., Ltd

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Shanghai Macklin Biochemical Co.,Ltd.

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Shanghai Lollane Biological Technology Co.,Ltd.

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Shanghaizehan biopharma technology co., Ltd.

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ShangHai Angti Biotechnology Co., Ltd.

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