Basic information Safety Supplier Related

SB242235

Basic information Safety Supplier Related

SB242235 Basic information

Product Name:
SB242235
Synonyms:
  • SB-242235; SB242235
  • CS-668
  • SB242235
  • 4-[4-(4-Fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxypyrimidine
  • 4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-iMidazol-5-yl)-2-MethoxypyriMidine
  • SB242235 ≥95%
  • Pyrimidine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxy-
  • inhibit,SB 242235,Autophagy,Inhibitor,p38 MAPK
CAS:
193746-75-7
MF:
C19H20FN5O
MW:
353.39
Mol File:
193746-75-7.mol
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SB242235 Chemical Properties

Boiling point:
568.4±60.0 °C(Predicted)
Density 
1.34
storage temp. 
2-8°C(protect from light)
solubility 
DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml
form 
Powder
pka
9.91±0.10(Predicted)
color 
White to off-white
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Safety Information

HS Code 
2924297099
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SB242235 Usage And Synthesis

Biological Activity

SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 μM in human chondrocytes.

in vitro

SB 242235 (0-10 μM) dose-dependently inhibits the activation of MAPKAP K2 with an IC 50 of 1.0 μM in human chondrocytes stimulated with IL-1β.
SB 242235 inhibits intracellular p38 activity, MAPKAP K2 was then isolated from these cells and assayed using HSP27 as a substrate.

Western Blot Analysis

< td class="col2"> 15 minutes
Cell Line: Human chondrocytes
Concentration: 0 μM, 0.01 μM, 0.1 μM, 1 μM, 10 μM
Incubation Time:
Result: Dose-dependently inhibited the activation of MAPKAP K2 with an IC 50 of 1.0 μM.

target

IC50: 1.0 μM (p38 MAPK, primary human chondrocytes)

SB242235Supplier

Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Email
info@chemexpress.com
SYN|thesis med chem P/L
Tel
+86-021-50720296
Email
service@synkinase.com
ShangHai YingYi Chemical Technology Co., Ltd.
Tel
86-21-50700185 13764109623
Email
sale@inyelchem.com
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Email
info@adooq.cn
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SB242235(193746-75-7)Related Product Information