5-AMINO-1-N-METHYLINDOLE Chemical Properties

Melting point:

102 °C

Boiling point:

143-144 °C(Press: 2 Torr)

Density 

1.15±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Acetonitrile (Slightly), Chloroform (Slightly)

form 

Solid

pka

5.05±0.10(Predicted)

color 

Black

CAS DataBase Reference

102308-97-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

36/37/38-36-22-20/21/22

Safety Statements 

36/37/39-26-22

RIDADR 

2811

HazardClass 

IRRITANT

HS Code 

29339900

5-AMINO-1-N-METHYLINDOLE Usage And Synthesis

Chemical Properties

Brown solid

Uses

5-Amino-1-N-methylindole (CAS# 102308-97-4) is an indole derivative and building block, used in the copper-catalyzed synthesis of sulfonamides.

Synthesis

The general procedure for the synthesis of 1-methyl-5-aminoindole using 1-methyl-5-nitroindole as starting material was as follows: 10% Pd/C catalyst (0.18 g/g by mass of the feedstock) was added to the feedstock solution (THF dosage of 54 mL/g of feedstock) dissolved in THF. The reaction flask was sealed and air was removed by vacuum. Subsequently, a hydrogen-filled balloon was attached to the flask. The reaction was stirred continuously at room temperature for 24 to 48 hours or monitored by TLC until the feedstock completely disappeared. Upon completion of the reaction, the mixture was filtered through diatomaceous earth. The filtrate was collected and the solvent was removed by rotary evaporation to give a brown solid product in 100% yield. The structure of the product was confirmed by 1H NMR (DMSO-d6) and 13C NMR (DMSO-d6): 1H NMR (DMSO-d6): δ 7.15-7.05 (m, 2H), 6.71 (dd, J = 3.0, 0.9 Hz, 1H), 6.57 (dd, J = 8.5, 2.1 Hz, 1H), 6.12 (dd, J = 3.0, 0.9 Hz, 1H), 3.67 (s, 3H); 13C NMR (DMSO-d6): δ 141.30, 131.12, 129.49, 129.44, 129.41, 112.31, 110.11, 104.21, 99.13, 32.86.

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 1202 - 1213
[2] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 10, p. 3531 - 3541
[3] New Journal of Chemistry, 2015, vol. 39, # 7, p. 5360 - 5365
[4] Patent: CN104163815, 2017, B. Location in patent: Paragraph 0065; 0066; 0068
[5] Patent: CN107163029, 2017, A. Location in patent: Paragraph 0049; 0053; 0054; 0055; 0056; 0057; 0058

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