2,2-Difluoropropionic acid Chemical Properties

Melting point:

38-45 °C

Boiling point:

25-30 °C/5 mmHg

Density 

1.316±0.06 g/cm3(Predicted)

Flash point:

25-30°C/5mm

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

pka

1.34±0.10(Predicted)

color 

White to Almost white

InChI

InChI=1S/C3H4F2O2/c1-3(4,5)2(6)7/h1H3,(H,6,7)

InChIKey

PMWGIVRHUIAIII-UHFFFAOYSA-N

SMILES

C(O)(=O)C(F)(F)C

CAS DataBase Reference

373-96-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

34-36

Safety Statements 

26-36/37/39

RIDADR 

3261

WGK Germany 

3

HazardClass 

8

PackingGroup 

III

HS Code 

29159000

2,2-Difluoropropionic acid Usage And Synthesis

Uses

2,2-Difluoropropionic acid is a useful research chemical.

Uses

2,2-Difluoropropionic acid is mainly used in biochemical research.

Chemical Properties

White powder

Synthesis

The general procedure for synthesizing 2,2-difluoropropionic acid from ethyl 2,2-difluoropropionate was as follows: referring to Example G38, ethyl 2,2-difluoropropionate (1.2 g, 8.8 mmol) was dissolved in ethanol (26 mL), followed by the slow addition of 2N aqueous sodium hydroxide solution (26 mL). The reaction mixture was stirred at 0 °C, then gradually warmed to room temperature and continued stirring for 14 hours. Upon completion of the reaction, the reaction mixture was acidified to pH < 7 with 2N hydrochloric acid and then extracted with ether. The organic phases were combined, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to give 2,2-difluoropropionic acid (0.90 g, 92% yield). The product was an oil with the following 1H-NMR (CDCl3) data: δ 1.85 (3H, t, J = 19.0 Hz), 6.21 (1H, br s).

References

[1] Patent: EP1402900, 2004, A1
[2] Patent: US2004/53973, 2004, A1
[3] Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, p. 1260 - 1263
[4] Zhurnal Organicheskoi Khimii, 1981, vol. 17, # 7, p. 1417 - 1420
[5] Journal of Organic Chemistry USSR (English Translation), 1982, vol. 18, p. 1597 - 1601

2,2-Difluoropropionic acid(373-96-6)Related Product Information

• 2-Bromopropionic acid
• Glycine
• Ethyl 2-(Chlorosulfonyl)acetate
• Fluticasone propionate
• Beclomethasone dipropionate
• 3,3'-Thiodipropionic acid
• Imidocarb dipropionate
• Folic acid
• Calcium Propionate
• Heptafluorobutyric acid
• Pentadecafluorooctanoic acid
• HEXAFLUOROGLUTARIC ACID
• DIETHYL TETRAFLUOROSUCCINATE
• METHYL HEPTAFLUOROBUTYRATE
• Perfluoropropionic anhydride
• ETHYL PERFLUOROHEPTANOATE
• HEXAFLUOROGLUTARIC ANHYDRIDE
• ETHYL PERFLUOROOCTANOATE