Propionyl-L-carnitine hydrochloride
Propionyl-L-carnitine hydrochloride Basic information
- Product Name:
- Propionyl-L-carnitine hydrochloride
- Synonyms:
-
- [3-carboxy-2-(1-oxopropoxy)propyl]-trimethylammonium chloride
- (R)-3-Carboxy-N,N,N-trimethyl-2-(propionyloxy)-1-propanaminium Chloride
- Propionyl-L-carnitine-d3 HCl
- Propionyl-L-carn
- 1-PropanaMiniuM,3-carboxy-N,N,N-triMethyl-2-(1-oxopropoxy)-, chloride (1:1), (2R)-
- (R)-3-(Propionyloxy)-4-(triMethylaMMonio)butanoate hydrochloride
- Propionyl-L-carnitine HCI(PLC)
- Levocarnitine propionate (hydrochloride)
- CAS:
- 119793-66-7
- MF:
- C10H20ClNO4
- MW:
- 253.72
- EINECS:
- 922-939-3
- Product Categories:
-
- ALDOMET
- Amino Acids & Derivatives
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 119793-66-7.mol
Propionyl-L-carnitine hydrochloride Chemical Properties
- Melting point:
- 165-167°C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 119793-66-7(CAS DataBase Reference)
Propionyl-L-carnitine hydrochloride Usage And Synthesis
Description
Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids. Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; ) and 6-keto-prostaglandin F1α in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 (TXB2; ) in non-contaminated cells. It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal. Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.
Chemical Properties
White Solid
Uses
antihypertensive
Uses
L-Propionyl carnitine has been shown to improve the heart's mechanical recovery and other metabolic parameters after ischemia-reperfusion.
Uses
L-Propionyl carnitine has been shown to improve the heart''s mechanical recovery and other metabolic parameters after ischemia-reperfusion.
brand name
Dromos (Biosint S.p.A.).
storage
+4°C
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Propionyl-L-carnitine hydrochloride(119793-66-7)Related Product Information
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- DL-Carnitine
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