4'-HYDROXYCHALCONE Chemical Properties

Melting point:

174-178 °C

Boiling point:

419.6±45.0 °C(Predicted)

Density 

1.191±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml

form 

powder to crystal

pka

7.72±0.15(Predicted)

color 

Light orange to Yellow to Green

BRN 

2049150

InChIKey

UAHGNXFYLAJDIN-IZZDOVSWSA-N

LogP

3.650 (est)

CAS DataBase Reference

2657-25-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26-37

HS Code 

29145090

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

4'-HYDROXYCHALCONE Usage And Synthesis

Description

4''-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6. 4''-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner. 4''-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC₅₀ = 47.3 μM) in vitro in a reversible and non-competitive manner.

Chemical Properties

yellow-cream powder

Uses

antineoplastic,

Uses

4''-Hydroxychalcone is a chalone derivative that exhibits moderate to good antiviral activity against tobacco mosaic virus (TMV).

Definition

ChEBI: A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4'.

4'-HYDROXYCHALCONE(2657-25-2)Related Product Information

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