DROFENINE HYDROCHLORIDE
DROFENINE HYDROCHLORIDE Basic information
- Product Name:
- DROFENINE HYDROCHLORIDE
- Synonyms:
-
- LABOTEST-BB LT00244841
- HEXAHYDROADIPHENINE HYDROCHLORIDE
- DROFENINE HYDROCHLORIDE
- hexahydroadiphenine
- DROFENINE HCL
- 2-(diethylamino)ethylalpha-cyclohexylbenzeneacetate
- 2-diethylaminoethyl(alpha-phenylcyclohexane)acetatehydrochloride
- adipheninehhydrochloride
- CAS:
- 548-66-3
- MF:
- C20H32ClNO2
- MW:
- 353.93
- EINECS:
- 208-954-1
- Mol File:
- 548-66-3.mol
DROFENINE HYDROCHLORIDE Chemical Properties
- Melting point:
- 145-147°
- storage temp.
- 2-8°C
- solubility
- Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly)
- form
- Solid
- color
- White to Off-White
MSDS
- Language:English Provider:SigmaAldrich
DROFENINE HYDROCHLORIDE Usage And Synthesis
Originator
Trasentine A,Ciba
Uses
Spasmolytic
Uses
Drofenine is a widely used anticholinergic drug. It acts on smooth muscle to stop muscle spasms.
Manufacturing Process
17.4 parts of diphenylacetic acid 2-(diethylamino)ethyl ester were solved in
200 parts of acetic acid and hydrogenated over platinum catalyst. After the
calculated volume of hydrogen was passed, the catalyst was filtered off and
the solvent was removed to dryness. Ether, water and a potassium carbonate
solution were added to the remaining oil and were thoroughly shaken. The
ether layer was washed with water and dried over potassium carbonate. The
solvent was removed, the remaining oil was distilled in vacuum to give 2-
(diethylamino)ethyl α-phenylcyclohexaneacetate; BP 150°-160°C/0.2 mm Hg.
In practice it is usually used as hydrochloride.
Therapeutic Function
Spasmolytic
DROFENINE HYDROCHLORIDESupplier
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DROFENINE HYDROCHLORIDE(548-66-3)Related Product Information
- ethyl 2-phenylbutyrate
- 2-Isopropyl-2-phenylacetic acid
- ETHYL 2-PHENYLPROPIONATE
- butetamate
- METHYL CYCLOHEXANEACETATE
- ETHYL CYCLOHEXYLACETATE
- CYCLOHEXYLPHENYLACETIC ACID
- Cyclohexylacetic acid
- 2-Phenylbutyric acid
- 2-DIETHYLAMINOETHANOL HYDROCHLORIDE
- 2-(diethylamino)ethyl 2-phenylbutyrate hydrochloride
- DROFENINE HYDROCHLORIDE
- methyl 2-phenylbutyrate
- Drofenine
- Prospasmin
- 3-METHYL-2-PHENYLVALERIC ACID
- ACETIC ACID, PHENYL-, 2-(DIETHYLAMINO)ETHYL ESTER
- 2-(Diethylamino)ethyl alpha-phenyl-beta-methylvalerate hydrochloride