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Butyl chloroformate

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Butyl chloroformate Basic information

Product Name:
Butyl chloroformate
Synonyms:
  • N-BUTYL CHLOROFORMATE
  • Butoxycarbonyl chloride
  • Butyl chloridocarbonate
  • Butyl chlorocarbonate
  • carbonochloridicacid,butylester
  • carbonochloridicacidbutylester
  • Formic acid, chloro-, butyl ester
  • BUTYL CHLOROCARBOXYLATE
CAS:
592-34-7
MF:
C5H9ClO2
MW:
136.58
EINECS:
209-750-5
Product Categories:
  • Acid Halides
  • Building Blocks
  • Acid Halides
  • Carbonyl Compounds
  • Chemical Synthesis
  • Organic Building Blocks
  • Pharmaceutical Intermediates
  • CHLOROFORMATES
  • Carbonyl Compounds
  • Organic Building Blocks
  • bc0001
Mol File:
592-34-7.mol
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Butyl chloroformate Chemical Properties

Melting point:
-70 °C
Boiling point:
142 °C(lit.)
Density 
1.074 g/mL at 25 °C(lit.)
vapor pressure 
2.42 psi ( 20 °C)
refractive index 
n20/D 1.412(lit.)
Flash point:
77 °F
storage temp. 
2-8°C
form 
Liquid
color 
Clear
Water Solubility 
DECOMPOSES
Sensitive 
Moisture Sensitive
BRN 
605635
LogP
1.895 (est)
CAS DataBase Reference
592-34-7(CAS DataBase Reference)
NIST Chemistry Reference
Carbonochloridic acid, butyl ester(592-34-7)
EPA Substance Registry System
n-Butyl chloroformate (592-34-7)
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Safety Information

Hazard Codes 
T
Risk Statements 
10-23-34
Safety Statements 
26-36-45
RIDADR 
UN 2743 6.1/PG 2
WGK Germany 
1
10-19
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
I
HS Code 
29159020

MSDS

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Butyl chloroformate Usage And Synthesis

Chemical Properties

clear liquid

Uses

Butyl Chloroformate is a reactant in the preparation of Lapatinib derivatives as HER1/HER2 targeting antitumor drugs.

General Description

A colorless liquid. Flash point near 70°F. Very toxic by inhalation. Denser than water. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Decomposes exothermically in water to give hydrochloric acid and organic acids.

Reactivity Profile

Butyl chloroformate is incompatible with bases (including amines), with water, with strong oxidizing agents, with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

Inhalation of vapor irritates nose and throat and can cause delayed pulmonary edema. Liquid irritates eyes and causes severe skin burns and irreversible skin damage if allowed to remain. Can cause blindness. Ingestion causes burns of mouth and stomach.

Flammability and Explosibility

Flammable

Butyl chloroformateSupplier

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