Butyl chloroformate Chemical Properties

Melting point:

-70 °C

Boiling point:

142 °C(lit.)

Density 

1.074 g/mL at 25 °C(lit.)

vapor pressure 

2.42 psi ( 20 °C)

refractive index 

n20/D 1.412(lit.)

Flash point:

77 °F

storage temp. 

2-8°C

form 

Liquid

color 

Clear

Water Solubility 

DECOMPOSES

Sensitive 

Moisture Sensitive

BRN 

605635

LogP

1.895 (est)

CAS DataBase Reference

592-34-7(CAS DataBase Reference)

NIST Chemistry Reference

Carbonochloridic acid, butyl ester(592-34-7)

EPA Substance Registry System

n-Butyl chloroformate (592-34-7)

Safety Information

Hazard Codes 

T

Risk Statements 

10-23-34

Safety Statements 

26-36-45

RIDADR 

UN 2743 6.1/PG 2

WGK Germany 

1

F 

10-19

TSCA 

TSCA listed

HazardClass 

6.1

PackingGroup 

I

HS Code 

29159020

MSDS

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Butyl chloroformate Usage And Synthesis

Chemical Properties

clear liquid

Uses

Butyl Chloroformate is a reactant in the preparation of Lapatinib derivatives as HER1/HER2 targeting antitumor drugs.

General Description

A colorless liquid. Flash point near 70°F. Very toxic by inhalation. Denser than water. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Decomposes exothermically in water to give hydrochloric acid and organic acids.

Reactivity Profile

Butyl chloroformate is incompatible with bases (including amines), with water, with strong oxidizing agents, with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

Inhalation of vapor irritates nose and throat and can cause delayed pulmonary edema. Liquid irritates eyes and causes severe skin burns and irreversible skin damage if allowed to remain. Can cause blindness. Ingestion causes burns of mouth and stomach.

Flammability and Explosibility

Flammable

Synthesis

The n-butyl chloroformate was prepared as follows: 1580g of n-butanol (M=74) was preheated to 100??C, added from the upper inlet of the reaction distillation tower using a stratospheric pump, and fully contacted with the phosgene gas (0.5MPa, M=98.9) entering from the lower inlet in the reaction section, which was 100??C. The liquid hydrogen chloride and the excess of hydrogen chloride were separated by deep condensation at -40??C through a heat exchanger into the reaction distillation tower for reuse. The generated hydrogen chloride and excess phosgene enter the subsequent recovery unit through the top of the tower and are separated by deep condensation at -40??C. The liquid phosgene passes through a heat exchanger into the reaction distillation tower for reuse, and the hydrogen chloride gas is passed into a 1.0 wt% NaOH aqueous solution for absorption. The n-butyl chloroformate as a single product stream passes through the tower kettle into the storage tank for subsequent use. The composition of the reaction solution was analyzed by gas chromatography, which showed that the conversion of butanol was >99.9% and the selectivity of chloroformate was >99.9%.

Butyl chloroformate(592-34-7)Related Product Information

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