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Paroxetine maleate

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Paroxetine maleate Basic information

Product Name:
Paroxetine maleate
Synonyms:
  • BRL-29060
  • FG-7051
  • (3S-TRANS)-3-[(1,3-BENZODIOXOL-5-YLOXY)METHYL]-4-(4-FLUOROPHENYL)PIPERIDINE MALEATE
  • (3S,4R)-3-[(1,3-BENZODIOXOL-5-YLOXY)METHYL]-4-(4-FLUOROPHENYL)-PIPERIDINE MALEATE
  • (-)-alpha-4-(4-fluorophenyl)-3-(1,3-benzdioxolyl-(3))-oxymethylpiperidinema
  • ,(z)-2-butenedioate
  • 3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-3-((trans-(-)-piperidin
  • PAROXETINE MALEATE
CAS:
64006-44-6
MF:
C23H24FNO7
MW:
445.44
EINECS:
636-343-3
Mol File:
64006-44-6.mol
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Paroxetine maleate Chemical Properties

Melting point:
136-138°C
alpha 
D -87° (c = 5 in ethanol)
Flash point:
9℃
storage temp. 
2-8°C
solubility 
DMSO: ~12 mg/mL
form 
solid
color 
white
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Safety Information

Hazard Codes 
Xn,T,F
Risk Statements 
22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements 
26-36-45-36/37-16-7
RIDADR 
3249
WGK Germany 
3
RTECS 
TM4569300
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 in mice (mg/kg): 845 s.c.; 500 orally (Christensen, Squires, 1977)

MSDS

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Paroxetine maleate Usage And Synthesis

Uses

Paroxetine maleate is a selective serotonin uptake inhibitor.

Definition

ChEBI: A maleate salt obtained by reaction of paroxetine with one equivalent of maleic acid. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibi ion of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2

General Description

Paroxetine, marketed under trade names such as Paxil? or Aropax, is an SSRI antidepressant used to treat many conditions in adults from major depression and obsessive-compulsive disorder to several anxiety disorders. Suitable uses for this certified solution standard include as a starting material for calibrators and controls in LC/MS or GC/MS paroxetine testing applications such as urine drug testing, prescription monitoring, clinical toxicology, or forensic analysis.

Biological Activity

Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (K i = 0.05 nM). K i values are 1.1, 350 and 1100 nM for inhibition of [ 3 H]-5-HT, [ 3 H]-l-NA and [ 3 H]-DA uptake respectively. Displays minimal affinity for a 1 -, a 2 - or b-adrenoceptors, 5-HT 2A , 5-HT 1A , D 2 or H 1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (K i = 42 nM). Antidepressant and anxiolytic in vivo .

Biochem/physiol Actions

Paroxetine is a strong cytochrome P450 2D6 isotype (CYP2D6) inhibitor, which reduces the effectiveness of tamoxifen. This phenylpiperidine derivative inhibits clozapine metabolism. Paroxetine is used to treat social phobia, obsessive-compulsive disorder and panic disorder. It is also used to treat the premenstrual dysphoric disorder, post-traumatic stress disorder and chronic headache.

storage

Store at RT

Paroxetine maleateSupplier

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