2,5-Dimethylnitrobenzene Chemical Properties

Melting point:

-25°C

Boiling point:

121°C 13mm

Density 

1.13

refractive index 

1.5400-1.5440

Flash point:

104℃

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Light orange to Yellow to Green

Stability:

Stable. Incompatible with strong bases, strong oxidizing agents.

CAS DataBase Reference

89-58-7(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1,4-dimethyl-2-nitro-(89-58-7)

EPA Substance Registry System

2-Nitro-p-xylene (89-58-7)

Safety Information

Risk Statements 

36/37-39/23/24/25

Safety Statements 

26-36/37/39-24/25

RIDADR 

1665

RTECS 

ZE4686600

HazardClass 

6.1

PackingGroup 

II

HS Code 

29042090

Toxicity

LD50 orl-rat: 2440 mg/kg 85JCAE -,420,86

MSDS

• Language:English Provider:1,4-Dimethyl-2-nitrobenzene

2,5-Dimethylnitrobenzene Usage And Synthesis

Chemical Properties

pale yellow liquid

Synthesis Reference(s)

Synthesis, p. 690, 1978 DOI: 10.1055/s-1978-24859

General Description

Clear pale yellow to amber liquid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2,5-Dimethylnitrobenzene is incompatible with strong oxidizers and strong bases .

Fire Hazard

2,5-Dimethylnitrobenzene is probably combustible.

Safety Profile

Moderately toxic by ingestion.Mutation data reported. When heated to decomposition itemits toxic vapors of NOx.

Synthesis

GENERAL STEPS: All reactions were carried out in a 50 mL two-necked round-bottomed flask equipped with a water condenser and a magnetic stirrer. In a typical experiment, a mixture of zeolite HBEA-25 (Si/Al = 25, 0.11 g), o-xylene (0.60 mL, 5 mmol), 65% nitric acid (0.68 mL, 10 mmol) with acetic anhydride (5.0 mL) was stirred and reacted for 10 h at room temperature. After completion of the reaction, the zeolite was removed by filtration and the filtrate was washed sequentially with NaHCO3 solution (3 x 10 mL) and distilled water (3 x 10 mL). The organic phase was separated, dried with anhydrous sodium sulfate and filtered to give a straw yellow liquid product. The isomer distribution and yield of the product were estimated by gas chromatography internal standard method based on peak area. The crude product was further purified by column chromatography and structural identification was carried out by comparing the analytical data with real samples.

References

[1] Russian Journal of Organic Chemistry, 1993, vol. 29, # 3.2, p. 457 - 466
[2] Zhurnal Organicheskoi Khimii, 1993, vol. 29, # 3, p. 546 - 558
[3] Tetrahedron Letters, 1996, vol. 37, # 4, p. 513 - 516
[4] Journal of Fluorine Chemistry, 2008, vol. 129, # 6, p. 524 - 528
[5] Organic Letters, 2018, vol. 20, # 11, p. 3197 - 3201

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