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Eperisone hydrochloride

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Eperisone hydrochloride Basic information

Product Name:
Eperisone hydrochloride
Synonyms:
  • EPERISONE HCL
  • EPERISONE HYDROCHLORIDE
  • (4'-ethyl-2-methyl-3-piperidino)propiophenone hydrochloride
  • 1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-1-propanonhydrochloride
  • 4’-ethyl-2-methyl-3-piperidino-propiophenonhydrochloride
  • e0646
  • e-646
  • empp
CAS:
56839-43-1
MF:
C17H26ClNO
MW:
295.85
EINECS:
1308068-626-2
Product Categories:
  • Aromatics
  • Heterocycles
  • Miscellaneous Biochemicals
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
56839-43-1.mol
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Eperisone hydrochloride Chemical Properties

Melting point:
169-171°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White
CAS DataBase Reference
56839-43-1(CAS DataBase Reference)
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Safety Information

Toxicity
LD50 in male S.D. rats, Wistar rats, mice (mg/kg): 1300, 1850, 1024 orally (Miyagawa)
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Eperisone hydrochloride Usage And Synthesis

Description

Eperisone hydrochloride is a centrally acting muscle relaxant useful in the management of various spastic conditions including cervical spondylosis and cerebral palsy. It is structurally related to tolperisone.

Chemical Properties

White Solid

Originator

Eisai (Japan)

Uses

A spasmolytic agent related structurally to Tolperisone (T535475). Muscle relaxant (skeletal).

Uses

Used as antispasmodic

Definition

ChEBI: Eperisone hydrochloride is an aromatic ketone.

Manufacturing Process

To 60 ml of isopropanol, there are introduced 120 g of 4-ethyl-propiophenone, 28.8g of p-formaldehyde and 107 g of piperidine hydrochloride, and the resulting mixture is heated to reflux on an oil bath with stirring. The heating is continued, and when the reaction mixture solidifies, the state being a sign of completion of the reaction, there are added 500 ml of acetone thereinto. The solidified mass is pulverized by crush, recovered by filtration and washed with acetone. 144 g of the crude dry crystalline substance is thus obtained, which is the hydrochloride of the purposed product. The hydrochloride is recrystallized from isopropanol, and there are obtained the crystalline needles having the melting point of 170°C to 172°C.

brand name

MYONAL

Therapeutic Function

Muscle relaxant

Eperisone hydrochlorideSupplier

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