Eperisone hydrochloride
Eperisone hydrochloride Basic information
- Product Name:
- Eperisone hydrochloride
- Synonyms:
-
- EPERISONE HCL
- EPERISONE HYDROCHLORIDE
- (4'-ethyl-2-methyl-3-piperidino)propiophenone hydrochloride
- 1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-1-propanonhydrochloride
- 4’-ethyl-2-methyl-3-piperidino-propiophenonhydrochloride
- e0646
- e-646
- empp
- CAS:
- 56839-43-1
- MF:
- C17H26ClNO
- MW:
- 295.85
- EINECS:
- 1308068-626-2
- Product Categories:
-
- Aromatics
- Heterocycles
- Miscellaneous Biochemicals
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 56839-43-1.mol
Eperisone hydrochloride Chemical Properties
- Melting point:
- 169-171°C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White
- CAS DataBase Reference
- 56839-43-1(CAS DataBase Reference)
Eperisone hydrochloride Usage And Synthesis
Description
Eperisone hydrochloride is a centrally acting muscle relaxant useful in the management of various spastic conditions including cervical spondylosis and cerebral palsy. It is structurally related to tolperisone.
Chemical Properties
White Solid
Originator
Eisai (Japan)
Uses
A spasmolytic agent related structurally to Tolperisone (T535475). Muscle relaxant (skeletal).
Uses
Used as antispasmodic
Definition
ChEBI: Eperisone hydrochloride is an aromatic ketone.
Manufacturing Process
To 60 ml of isopropanol, there are introduced 120 g of 4-ethyl-propiophenone, 28.8g of p-formaldehyde and 107 g of piperidine hydrochloride, and the resulting mixture is heated to reflux on an oil bath with stirring. The heating is continued, and when the reaction mixture solidifies, the state being a sign of completion of the reaction, there are added 500 ml of acetone thereinto. The solidified mass is pulverized by crush, recovered by filtration and washed with acetone. 144 g of the crude dry crystalline substance is thus obtained, which is the hydrochloride of the purposed product. The hydrochloride is recrystallized from isopropanol, and there are obtained the crystalline needles having the melting point of 170°C to 172°C.
brand name
MYONAL
Therapeutic Function
Muscle relaxant
Eperisone hydrochlorideSupplier
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