4-Hydroxyisophthalonitrile Chemical Properties

Boiling point:

319℃

Density 

1.34

Flash point:

150℃

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

5.04±0.18(Predicted)

color 

Pale Beige

Safety Information

HS Code 

2926907090

4-Hydroxyisophthalonitrile Usage And Synthesis

Uses

4-Hydroxy-1,3-benzenedicarbonitrile is used in the preparation of febuxostat (F229000), a non-purine xanthine oxidase inhibitor used as a treatment for hyperuricaemia and chronic gout.

4-Hydroxyisophthalonitrile(34133-58-9)Related Product Information

• 2-[3-(AMinocarbonyl)-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid
• 1-Bromo-2-methylpropane
• 2-(3-cyano-4-propoxyphenyl)-4-methylthiazole-5-carboxylic acid
• Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
• 4-HYDROXYTHIOBENZAMIDE
• Febuxostat Descyano Impurity
• Febuxostat Acyl-β-D-glucuronide
• 4-(2-Methylpropoxy)-1,3-benzenedicarbonitrile
• ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
• ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
• isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
• Febuxostat Impurity 8
• 4-(2-Methylpropoxy)-1,3-benzenedicarbothioaMide
• ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
• Febuxostat Impurity 46
• 2-(4-butoxy-3-cyanophenyl)-4-methylthiazole-5-carboxylic acid
• ethyl 2-(3-hydroxyphenyl)-4-methylthiazole-5-Carboxylate
• 4-Aminophenol