Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Plant extracts >  gracillin

gracillin

Basic information Safety Supplier Related

gracillin Basic information

Product Name:
gracillin
Synonyms:
  • Gracillin, 98%, from Dioscorea opposita Thunb.
  • (25R)-3β-(2-O-α-L-Rhamnopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyloxy)spirosta-5-ene
  • [(25R)-Spirost-5-en-3β-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-3-O-(β-D-glucopyranosyl)-β-D-glucopyranoside
  • [(25R)-Spirosta-5-ene-3β-yl]3-O-β-D-glucopyranosyl-2-O-α-L-rhamnopyranosyl-β-D-glucopyranoside
  • Diosgenin 3-O-β-gracillimatrioside
  • Gracilline
  • Diosgenin 3-O-beta-gracillimatrioside
  • DulcaMarinC
CAS:
19083-00-2
MF:
C45H72O17
MW:
885.04
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
19083-00-2.mol
More
Less

gracillin Chemical Properties

Melting point:
290-293℃ (DEC.)
Density 
1.42
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in DMSO, methanol and pyridine
form 
powder
pka
12.78±0.70(Predicted)
color 
White
InChI
InChI=1S/C15H20O3/c1-8-4-5-11(16)15(3)7-6-10-9(2)14(17)18-13(10)12(8)15/h9-10,13H,4-7H2,1-3H3
InChIKey
RSDQBPGKMDFRHH-UHFFFAOYSA-N
SMILES
C12=C(C)CCC(=O)C1(C)CCC1C(C(=O)OC21)C
More
Less

Safety Information

HS Code 
29329990
More
Less

gracillin Usage And Synthesis

Description

Gracillin is a steroidal saponin that has been found in C. speciosus and has diverse biological activities. It reduces cell growth in a panel of 58 leukemia, non-small cell lung, colon, CNS, prostate, melanoma, ovarian, renal, and breast cancer cell lines (GI50s = 0.58-2.44 μM). Gracillin reduces growth of fish Ich parasite (I. multifiliis) theronts (EC50 = 0.53 mg/L) and induces 100 and 92.5% mortality of I. multifiliis protomonts and encysted tomonts, respectively, when used at a concentration of 0.8 mg/L. It decreases the number of I. multifiliis-infected goldfish by approximately 75% when used at a concentration of 1 mg/L in tank water. Gracillin (100 mg/kg) reduces ear edema induced by arachidonic acid in mice.

Chemical Properties

White powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the rhizomes of Dioscorea zingiberensis and Dioscorea parviflora.

Uses

Gracillin is a steroidal glycoside from the rhizomes of the family Dioscoreaceae with potential anti-proliferative effects.

Definition

ChEBI: Gracillin is a triterpenoid.

in vivo

Gracillin (oral gavage, 10?mg/kg for xenografts and 20?mg/kg for PDX) inhibits tumor growth of xenograft tumors inoculating lung (H1299), prostate (DU145), and colorectum (HCT116) cancer cells, as well as patient-derived xenograft colon and lung tumors[1].

References

[1] KE HU  Xinsheng Y. The cytotoxicity of methyl protoneogracillin (NSC-698793) and gracillin (NSC-698787), two steroidal saponins from the rhizomes of Dioscorea collettii var. hypoglauca, against human cancer cells in vitro.[J]. Phytotherapy Research, 2003, 17 6: 620-626. DOI: 10.1002/ptr.1211
[2] WEI ZHENG. Antiparasitic efficacy of Gracillin and Zingibernsis newsaponin from Costus speciosus (Koen ex. Retz) Sm. against Ichthyophthirius multifiliis.[J]. Parasitology, 2015, 142 3: 473-479. DOI: 10.1017/s0031182014001358
[3] SUNG YONG KIM. Inhibition of mouse ear edema by steroidal and triterpenoid saponins[J]. Archives of Pharmacal Research, 1999, 22 3: 313-316. DOI: 10.1007/bf02976370

gracillinSupplier

Nanjing Spring & Autumn Biological Engineering Co., Ltd. Gold
Tel
025-84430028 13815430202
Email
sale02@cqherb.com
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Email
sales@BioChemBest.com
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Email
chenyj@titansci.com
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Email
cdhxsj@163.com
More
Less

gracillin(19083-00-2)Related Product Information