FMOC-S-trityl-L-cysteine
FMOC-S-trityl-L-cysteine Basic information
- Product Name:
- FMOC-S-trityl-L-cysteine
- Synonyms:
-
- FMOC-CYSTEINE(TRT)-OH
- FMOC-CYS(TRT)
- FMOC-CYS(TRT)-OH
- FMOC-L-CYSTEINE(TRITYL)
- FMOC-L-CYSTEINE (TRT)
- FMOC-L-CYS(TRITYL)
- FMOC-L-CYS(TRT)
- FMOC-L-CYS(TRT)-OH
- CAS:
- 103213-32-7
- MF:
- C37H31NO4S
- MW:
- 585.71
- EINECS:
- 600-408-4
- Product Categories:
-
- Cysteine [Cys, C]
- Fmoc-Amino Acids and Derivatives
- Pharmaceutical Intermediates
- Fluorenes, Flurenones
- Amino Acids
- Fmoc-Amino acid series
- Amino Acids (N-Protected)
- Biochemistry
- Fmoc-Amino Acids
- Mol File:
- 103213-32-7.mol
FMOC-S-trityl-L-cysteine Chemical Properties
- Melting point:
- 170-173 °C(lit.)
- alpha
- 16 º (c=1, THF)
- Boiling point:
- 763.4±60.0 °C(Predicted)
- Density
- 1.270±0.06 g/cm3(Predicted)
- refractive index
- 18 ° (C=1, THF)
- storage temp.
- 2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- pka
- 3.70±0.10(Predicted)
- form
- Powder
- color
- White to almost white
- optical activity
- [α]20/D +16.0±2°, c = 1% in THF
- Water Solubility
- Insoluble in water. Soluble in most organic solvents.
- BRN
- 4221286
- InChIKey
- KLBPUVPNPAJWHZ-UMSFTDKQSA-N
- CAS DataBase Reference
- 103213-32-7(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-26
- WGK Germany
- 3
- F
- 9-21
- Hazard Note
- Irritant
- HS Code
- 29309090
MSDS
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
FMOC-S-trityl-L-cysteine Usage And Synthesis
Chemical Properties
white to light yellow crystal powde
Uses
It is potentially useful for proteomics studies, and solid phase peptide synthesis techniques. Cysteine is versatile amino acid involved with many biological processes, including the formation of disulfide bonds - a critical component of protein structure. This compound could be useful as an unusual amino acid analog to aid in the deconvolution of protein structure and function.
Uses
Fmoc-Cys(Trt)-OH is an N-terminal protected cysteine derivative used in peptide synthesis. Some of the examples are:
- Synthesis of mono- and bi-functionalized platinum(IV) complexes to target angiogenic tumor vasculature.
- Synthesis of proteins through native chemical ligation of peptide hydrazides as thioester surrogates via solid-phase synthesis.
- Synthesis of glycoconjugates by conjugating reducing sugars to cysteine residues of peptides.
General Description
The standard derivative for Fmoc SPPS of peptides containing Cys [1]. The Trt group is removed with 95% TFA containing 1-5% TIS. Ideally, this derivative should be introduced using the symmetrical anhydride or DIPCDI/HOBt activation [2,3] to minimize enantiomerization. If activation with uronium or phosphonium reagents, such as HBTU or PyBOP?, is to be employed, it is strongly recommended that collidine is used as the base [4], as this has been shown to significantly reduce loss of optical integrity during coupling.
The product number for this product was previously 04-12-1018.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.
FMOC-S-trityl-L-cysteineSupplier
- Tel
- 400-0066400 13621662912
- sales@jonln.com
- Tel
- 028-85371958
- yoo@yoochem.com
- Tel
- 13912331843
- sales02@gtaipeptide.com
- Tel
- 021-61263455 13167021076
- amy@glschina.com
- Tel
- 028-61682518; 19983060238
- sales@tachem.cn
FMOC-S-trityl-L-cysteine(103213-32-7)Related Product Information
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