2-Ethoxybenzaldehyde Chemical Properties

Melting point:

20-22 C

Boiling point:

136-138 °C/24 mmHg (lit.)

Density 

1.074 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.543(lit.)

Flash point:

197 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

Light yellow to yellow Liquid

Sensitive 

Air Sensitive

BRN 

1937270

LogP

2.250 (est)

CAS DataBase Reference

613-69-4(CAS DataBase Reference)

NIST Chemistry Reference

Benzaldehyde, 2-ethoxy-(613-69-4)

EPA Substance Registry System

Benzaldehyde, 2-ethoxy- (613-69-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-37/39-36

WGK Germany 

3

TSCA 

Yes

HS Code 

29122990

MSDS

• Language:English Provider:2-Ethoxybenzaldehyde
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Ethoxybenzaldehyde Usage And Synthesis

Chemical Properties

clear yellow to light brown liquid

Uses

2-Ethoxybenzaldehyde was used to study the 1,3-dipolar cycloaddition reactions.

Synthesis Reference(s)

Synthetic Communications, 19, p. 3407, 1989 DOI: 10.1080/00397918908052747

Synthesis

The general procedure for the synthesis of 2-ethoxybenzaldehyde from o-ethoxybenzyl alcohol was as follows: first, o-ethoxybenzyl alcohol (100 mg, 0.818 mmol), SS-Pd catalyst (918 mg, containing 0.04 mmol Pd), and 3 ml of toluene were mixed and the reaction mixture was purged with molecular oxygen. Subsequently, the reaction was stirred at 110 °C for 5 h, during which the reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was cooled to room temperature, diluted with ethyl acetate and filtered through a cotton bed. The combined organic layers were concentrated by evaporation under reduced pressure and the crude product obtained was purified by silica gel (60-120 mesh) column chromatography (eluent was 95:5 hexane/ethanol solvent mixture) to give 2-ethoxybenzaldehyde (94 mg, 96% yield) as a colorless liquid.

References

[1] Tetrahedron Letters, 2001, vol. 42, # 31, p. 5199 - 5201
[2] Tetrahedron Letters, 2013, vol. 54, # 23, p. 2924 - 2928
[3] Tetrahedron Letters, 2011, vol. 52, # 38, p. 4954 - 4956
[4] Canadian Journal of Chemistry, 2008, vol. 86, # 8, p. 782 - 790

2-Ethoxybenzaldehyde(613-69-4)Related Product Information

• 4-Dimethylaminobenzaldehyde
• 2-Nitrobenzaldehyde
• 4-Hydroxybenzaldehyde
• Salicylaldehyde
• 2-(Trifluoromethyl)benzaldehyde
• 3-Methoxybenzaldehyde
• o-Anisaldehyde
• Benzaldehyde
• 2-Ethoxyphenol
• Ethoxyquin
• p-Anisaldehyde
• 2-Ethoxybenzoic acid
• KHELLIN
• MERSALYL ACID
• NAPHTHOL AS ACETATE
• sodium benzaldehyde-o-sulfonate
• O-ACETYLSALICYLOYL CHLORIDE
• Rotenone