(R)-1-Boc-3-(hyroxymethyl)piperidine Chemical Properties

Melting point:

77-81 °C

Boiling point:

308.0±15.0 °C(Predicted)

Density 

1.059±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

14.93±0.10(Predicted)

form 

Powder

color 

White to yellow

Water Solubility 

Slightly soluble in water.

InChI

InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-6-4-5-9(7-12)8-13/h9,13H,4-8H2,1-3H3/t9-/m1/s1

InChIKey

OJCLHERKFHHUTB-SECBINFHSA-N

SMILES

N1(C(OC(C)(C)C)=O)CCC[C@@H](CO)C1

CAS DataBase Reference

140695-85-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,N,T

Risk Statements 

25-36-50

Safety Statements 

26-45-61

RIDADR 

UN2811

HS Code 

2933399990

(R)-1-Boc-3-(hyroxymethyl)piperidine Usage And Synthesis

Uses

(R)-(-)-1-Boc-3-(hydroxymethyl)piperidine is used as pharmaceutical intermediate.

Synthesis

The general procedure for the synthesis of tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate from (R)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid is as follows: Example 58: Synthesis of N-(2-methylpropyl)-N-(3,5-dichlorophenyl)methyl-(3R)-piperidin-3-ylmethylamine 1.5L-tartrate: (i) Borane-tetrahydrofuran complex (1 M solution of THF, 65.4 mL, 65.4 mmol, 3 eq.) was slowly added dropwise to a solution of (R)-(-)-N-Boc-piperidinic acid (5 g, 21.8 mmol, 1 eq.) in THF (50 mL) at room temperature. The reaction mixture was stirred at room temperature for 16 hours. Subsequently, the solution was cooled to 0 °C and hydrolyzed by careful addition of 2N aqueous sodium hydroxide solution (250 mL). After hydrolysis, the mixture was heated and kept for 48 hours. After completion of the reaction, the mixture was again cooled to 0 °C and extracted with ether (3 x 100 mL). The organic layers were combined, washed with brine (100 mL), dried over magnesium sulfate, filtered and concentrated in vacuum. The residue was purified by fast chromatography using an isohexane solution of 50-70% ethyl acetate as eluent to afford tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate (4.56 g, 98% yield). 1H NMR (300 MHz, CDCl3) δ: 4.0-2.7 (6H, br m), 2.17-1.19 (5H, br m), 1.46 (9H, s).

References

[1] Patent: WO2005/118531, 2005, A1. Location in patent: Page/Page column 74
[2] Patent: WO2006/12308, 2006, A1. Location in patent: Page/Page column 68
[3] Patent: WO2017/103611, 2017, A1. Location in patent: Paragraph 00298

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