N-(p-Aminobenzoyl)glutamic acid Chemical Properties

Melting point:

~175 °C (dec.)

alpha 

-15 º (c=2% in 0.1N HCl)

Boiling point:

409.45°C (rough estimate)

Density 

1.2846 (rough estimate)

refractive index 

1.6660 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

Aqueous Base (Sparingly), Aqueous Acid (Sparingly), DMSO (Sparingly)

form 

Solid

pka

3.50±0.10(Predicted)

color 

White to Light

Merck 

14,426

BRN 

2816320

Stability:

Hygroscopic

InChIKey

GADGMZDHLQLZRI-VIFPVBQESA-N

CAS DataBase Reference

4271-30-1(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

WGK Germany 

3

HS Code 

2924296000

MSDS

• Language:English Provider:N-(4-Aminobenzoyl)-L-glutamic acid
• Language:English Provider:SigmaAldrich

N-(p-Aminobenzoyl)glutamic acid Usage And Synthesis

Chemical Properties

Light Tan Waxy Solid

Uses

Marker in folate metabolism studies.

Uses

Major metabolite of 5-Methyltetrahydrofolic Acid

Definition

ChEBI: A dipeptide resulting from the formal condensation of the carboxylic acid group of 4-aminobenzoic acid with the amino group of L-glutamic acid.

Biological Activity

N-p-Aminobenzoyl)-L-glutamic acid is a folate catabolite th at can be metabolized by bacterial p-aminobenzoate auxotrophs possessing the enzyme p-aminobenzoyl-glutamate hydrolase.

Purification Methods

Crystallise the acid from H2O. Also purify it by dissolving 2.7g in H2O (130mL), adding aqueous NaOH to pH 5.5 and adding portionwise a solution of 0.5M CuSO4 to complete precipitation of the Cu salt. This salt is filtered off, suspended in H2O and H2S is bubbled through to precipitate CuS, filter, evaporate and recrystallise the residue from H2O. It has max (H2O) at 273nm. [Backer & Houtman Recl Trav Chim Pays-Bas 70 738, 743 1951, Beilstein 14 IV 1153.]

N-(p-Aminobenzoyl)glutamic acid(4271-30-1)Related Product Information

• Benzoyl peroxide
• TEA-LAUROYL GLUTAMATE
• N-Formylmorpholine
• P-AMINOBENZAMIDE GLUTAMIC ACID
• L-Glutamic acid
• L-Tetrahydrofolic Acid
• FOLIC ACID IMP. A (EP): N-(4-AMINOBENZOYL)-L-GLUTAMIC ACID MM(CRM STANDARD),FOLIC ACID IMP. A (EP): N-(4-AMINOBENZOYL)-L-GLUTAMIC ACID MM(CRM STANDARD)
• 4-Aminobenzoic acid
• p-Aminobenzamide
• Glutamic acid
• 2-Amino-7-(chloromethyl)pteridin-4(1H)-one
• Levomefolate calcium
• 6-hydroxymethylpterin
• Folic Acid Impurity C
• (2S)-2-[[4-[Bis[(2-aMino-4-oxo-1,4-dihydropteridin-6-yl)Methyl]aMino]benzoyl]aMino]pentanedioic Acid
• Folitixorin (Mixture of DiastereoMers)
• 2-Amino-4-hydroxy-1H-pteridine
• N-(4-aminobenzoyl)- D-Glutamic acid