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N-(p-Aminobenzoyl)glutamic acid

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N-(p-Aminobenzoyl)glutamic acid Basic information

Product Name:
N-(p-Aminobenzoyl)glutamic acid
Synonyms:
  • H-4-ABZ-GLU-OH
  • N-(P-AMINOBENZOYL)-L-GLUTAMIC ACID
  • P-AMINOBENZOYL-L-GLUTAMIC ACID
  • P-AMINO BENZAMIDE GLUTAMIC ACID
  • N-(4-AMINOBENZOYL)-L-GLUTAMIC ACID
  • N-(4-Aminobenzoyl)-L-Glutaminic Acid
  • L-Glutamic acid, N-(4-aminobenzoyl)-
  • N-(p-Aminobenzoyl)glutamic acid
CAS:
4271-30-1
MF:
C12H14N2O5
MW:
266.25
EINECS:
224-261-7
Product Categories:
  • amino
  • Intermediate
  • Amino Acids
  • A - HPeptide Synthesis
  • Amino Acids & Derivatives
  • Metabolites & Impurities
  • Amino Acid Derivatives
  • Amino Acids
  • Glutamic Acid
  • Modified Amino Acids
  • 4271-30-1
Mol File:
4271-30-1.mol
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N-(p-Aminobenzoyl)glutamic acid Chemical Properties

Melting point:
~175 °C (dec.)
alpha 
-15 º (c=2% in 0.1N HCl)
Boiling point:
409.45°C (rough estimate)
Density 
1.2846 (rough estimate)
refractive index 
1.6660 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Aqueous Base (Sparingly), Aqueous Acid (Sparingly), DMSO (Sparingly)
form 
Solid
pka
3.50±0.10(Predicted)
color 
White to Light
Merck 
14,426
BRN 
2816320
Stability:
Hygroscopic
InChIKey
GADGMZDHLQLZRI-VIFPVBQESA-N
CAS DataBase Reference
4271-30-1(CAS DataBase Reference)
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Safety Information

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
3
HS Code 
2924296000

MSDS

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N-(p-Aminobenzoyl)glutamic acid Usage And Synthesis

Chemical Properties

Light Tan Waxy Solid

Uses

Major metabolite of 5-Methyltetrahydrofolic Acid

Uses

Marker in folate metabolism studies.

Definition

ChEBI: A dipeptide resulting from the formal condensation of the carboxylic acid group of 4-aminobenzoic acid with the amino group of L-glutamic acid.

Purification Methods

Crystallise the acid from H2O. Also purify it by dissolving 2.7g in H2O (130mL), adding aqueous NaOH to pH 5.5 and adding portionwise a solution of 0.5M CuSO4 to complete precipitation of the Cu salt. This salt is filtered off, suspended in H2O and H2S is bubbled through to precipitate CuS, filter, evaporate and recrystallise the residue from H2O. It has max (H2O) at 273nm. [Backer & Houtman Recl Trav Chim Pays-Bas 70 738, 743 1951, Beilstein 14 IV 1153.]

N-(p-Aminobenzoyl)glutamic acid Preparation Products And Raw materials

Raw materials

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