8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE Basic information
- Product Name:
- 8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
- Synonyms:
-
- 8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
- WAY 161503 HYDROCHLORIDE
- WAY 161503
- 1H-Pyrazino[1,2-a]quinoxalin-5(6H)-one, 8,9-dichloro-2,3,4,4a-tetrahydro-
- WAY 161503 hydrochlo
- (Rac) WAY 161503,(Rac)WAY161503
- CAS:
- 75704-24-4
- MF:
- C11H11Cl2N3O
- MW:
- 272.13
- Product Categories:
-
- Serotonin receptor
- Mol File:
- 75704-24-4.mol
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8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE Chemical Properties
- Boiling point:
- 513.9±50.0 °C(Predicted)
- Density
- 1.54±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at RT
- solubility
- DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml
- form
- A crystalline solid
- pka
- 12.09±0.20(Predicted)
- color
- Off-white to light yellow
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8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE Usage And Synthesis
Uses
8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one is a selective 5-hydroxytryptamine 2C receptor agonist with putative antidepressant like properties. It also blocks and decreases baseline nicotine-induced locomotor activity in rats.
Biological Activity
Potent and selective 5-HT 2C receptor agonist (K i = 4 nM; EC 50 = 12 nM). Antidepressant following systemic administration in vivo .
8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDESupplier
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8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE(75704-24-4)Related Product Information
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- Aniline hydrochloride
- Pyridine hydrochloride
- Trimethylamine hydrochloride
- Methylamine hydrochloride
- N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE
- Wash Buffer (20x), 100 mL
- WASP (B-9)
- WAPL (A-7)
- WATER, ELECTROPHORESIS GRADE
- WAP (E-8)
- 1-(3,4-Dichlorophenyl)piperazine
- 2-Piperazinecarboxamide
- 7-CHLORO-3,4-DIHYDRO-1H-QUINOXALIN-2-ONE
- 8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
- 6-Chloro-1,2,3,4-tetrahydro-quinoxaline
- 1-(4-Chlorophenyl)-2-methylpiperazine