2-Amino-6-fluorobenzothiazole Chemical Properties

Melting point:

183-185 °C (lit.)

Boiling point:

312.0±34.0 °C(Predicted)

Density 

1.3490 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

3.77±0.10(Predicted)

form 

Crystalline Powder

color 

Off-white to tan

InChI

InChI=1S/C7H5FN2S/c8-4-1-2-5-6(3-4)11-7(9)10-5/h1-3H,(H2,9,10)

InChIKey

CJLUXPZQUXVJNF-UHFFFAOYSA-N

SMILES

S1C2=CC(F)=CC=C2N=C1N

CAS DataBase Reference

348-40-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-37/39-36/37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29342000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Amino-6-fluorobenzothiazole Usage And Synthesis

Structure

Crystals of 2-amino-6-fluoro-1,3-benzothiazole, C7H5FN2S, have an amphiphilic layer-like structure. Each amino substituent donates two protons to hydrogen bonds and accepts one. The ring N atoms accept one proton. The F atoms are not involved in any hydrogen bonds.

Chemical Properties

off-white to tan crystalline powder

Uses

2-Amino-6-fluorobenzothiazole is a useful research chemical. An intermediate for the synthesis of benzothiazoles and aminobenzothiazoles with antimicrobial activity.

Definition

ChEBI: 6-Fluoro-1,3-benzothiazol-2-amine is a member of benzothiazoles.

Application

2-Amino-6-fluorobenzothiazole (AFBT) can be used for:
(1) Interaction of AFBT with β-cyclodextrin (β-CDx) in aqueous and solid state. The proton transfer behaviour of AFBT in aqueous and β-CDx solutions was studied.
(2) Spectroscopic studies. Fourier transform infrared spectroscopy (4000-400 cm-1) and Fourier transform Raman spectroscopy (4000-100 cm-1) measurements were carried out on AFBT to investigate the effect of fluorine and amino groups on the backbone pattern and proton chemical shifts.

2-Amino-6-fluorobenzothiazole(348-40-3)Related Product Information

• 2-Aminothiazole
• Sulfamic acid
• 2-Mercaptobenzothiazole
• Tris(hydroxymethyl)aminomethane
• 2-Benzothiazolamine
• 2-Amino-6-chlorobenzothiazole
• 6-Aminocaproic acid
• Benzothiazole
• Glycine
• 3-Aminophenol
• ALTRENOGEST
• Glucosamine
• EC 2.6.1.2
• Dinitramine
• Acetaminophen
• Aminopyrine
• 2,2'-Dithiobis(benzothiazole)
• Fluorine