4-Hydroxyquinoline Chemical Properties

Melting point:

200-202 °C(lit.)

Boiling point:

264.27°C (rough estimate)

Density 

1.1555 (rough estimate)

refractive index 

1.4500 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in methanol.

form 

Crystalline Powder or Needles

pka

2.23, 11.28(at 20℃)

color 

Light beige to yellow

Water Solubility 

4.8g/L(15 ºC)

BRN 

1524969

InChIKey

PMZDQRJGMBOQBF-UHFFFAOYSA-N

LogP

2.450 (est)

CAS DataBase Reference

611-36-9(CAS DataBase Reference)

NIST Chemistry Reference

4-Quinolinol(611-36-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

VC4070000

HS Code 

29334900

MSDS

• Language:English Provider:4-Quinolinol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Hydroxyquinoline Usage And Synthesis

Description

4-Hydroxyquinoline is a quinoline alkaloid that has been found in Z. lotus honeys. It is a core component of alkyl-4-hydroxyquinoline quorum sensing molecules such as 2-heptyl-3-hydroxy-4(1H)-quinolone and 2-nonyl-3-hydroxy-4-quinolone. 4-Hydroxyquinoline has been used as a precursor in the synthesis of compounds with antibacterial activity. It has also been used as a fluorescent detection reagent for iron(III) in bovine liver samples.

Chemical Properties

LIGHT BEIGE TO YELLOWISH CRYST. POWDER OR NEEDLES

Uses

4-Hydroxyquinolineis a hydroxylated quinoline derivative with antimicrobial activity. 4-Hydroxyquinoline showed growth-inhibitory effects against intestinal bacteria. 4-Hydroxyquinoline act as sacrifi cial scavengers of the photogenerated oxygen species and has been shown to prevent the photodegradation of riboflavin.

Uses

4-Hydroxyquinoline is a medical raw material.

Definition

ChEBI: A monohydroxyquinoline carrying a hydroxy group at position 4.

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1264, 1946 DOI: 10.1021/ja01211a038

General Description

4-Quinolinol (4-quinolone) is a quinolone compound which forms the core moiety of antibacterials such as norfloxacin, nalidixic acid, ciprofloxacin and cinoxacin.

Biological Activity

4-hydroxyquinoline is a hydroxylated quinoline derivative with antimicrobial activity. it shows growth-inhibitory effects against intestinal bacteria. it also can be used as sacrificial scavengers of the photogenerated oxygen species.

4-Hydroxyquinoline(611-36-9)Related Product Information

• 2-Quinolinol
• 6-Hydroxyquinoline
• Quinhydrone
• 2,4-DIHYDROXYQUINOLINE MONOSODIUM SALT
• 8-Hydroxyquinoline potassium sulfate
• Tris(8-hydroxyquinolinato)erbium
• 8-HYDROXYQUINOLINE BASE
• BIS(2-METHYL-8-HYDROXYQUINOLINATO)ZINC
• 2,8-Bis(trifluoromethyl)-4-quinolinol
• 6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone
• ETHYL 6-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLATE
• 8-HYDROXYQUINOLINE-N-OXIDE
• 8-HYDROXYQUINOLINE, ZINC SALT
• 8-HYDROXYQUINOLINE COPPER SALT,8-HYDROXYQUINOLINE, COPPER(II) SALT,8-HYDROXYQUINOLINE, CU(II) SALT,COPPER 8-HYDROXYQUINOLINE,COPPER (II) 8-HYDROXYQUINOLINE
• 2,8-Quinolinediol
• 1,2,3,4-TETRAHYDRO-8-HYDROXYQUINOLINE
• 8-HYDROXYQUINOLINE BENZOATE
• 8-Hydroxyquinaldine