Aminoacetaldehyde dimethyl acetal
Aminoacetaldehyde dimethyl acetal Basic information
- Product Name:
- Aminoacetaldehyde dimethyl acetal
- Synonyms:
-
- AMINOACETOLDEHYDE DIMETHYL ACETOL
- 2,2-Dimetoxyethyl Amine
- 2,2-Dimethoxyethylamin
- Glycinal dimethyl acetal
- Aminoacetaldehyd Dimethy Acetal
- Aminoacetaldehyde dimethyl ace
- anjiahuanchun
- Aminoacetaldehyde dimethyl acetal ,98%
- CAS:
- 22483-09-6
- MF:
- C4H11NO2
- MW:
- 105.14
- EINECS:
- 245-026-5
- Product Categories:
-
- Pharmaceutical Intermediates
- 1
- 22483-09-6
- Mol File:
- 22483-09-6.mol
Aminoacetaldehyde dimethyl acetal Chemical Properties
- Melting point:
- -78°C
- Boiling point:
- 135-139 °C/95 mmHg (lit.)
- Density
- 0.965 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.417(lit.)
- Flash point:
- 128 °F
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- soluble in Chloroform, Methanol
- pka
- 6.95±0.10(Predicted)
- form
- Liquid
- color
- Clear colorless to pale yellow
- Water Solubility
- miscible
- BRN
- 741868
- InChIKey
- QKWWDTYDYOFRJL-UHFFFAOYSA-N
- CAS DataBase Reference
- 22483-09-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Aminoacetaldehyde dimethyl acetal(22483-09-6)
- EPA Substance Registry System
- Ethanamine, 2,2-dimethoxy- (22483-09-6)
Safety Information
- Hazard Codes
- C,F,Xi
- Risk Statements
- 10-34-36/37/38
- Safety Statements
- 26-36/37/39-45-16-36
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 2
- Hazard Note
- Flammable/Corrosive
- TSCA
- Yes
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29225000
MSDS
- Language:English Provider:2,2-Dimethoxyethylamine
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
Aminoacetaldehyde dimethyl acetal Usage And Synthesis
Description
Aminoacetaldehyde dimethyl acetal, also known as 2,2-dimethoxy-ethylamine, is a critical intermediate in the synthesis of ivabradine hydrochloride, proline analogs, praziquantel, and other raw materials. The existing process for producing aminoacetal dimethyl acetate uses vinyl acetate as the starting material, and the target product is synthesized through bromination, Gabriel synthesis, and hydrazinolysis.
Chemical Properties
clear colorless to pale yellow liquid
Uses
Amino acetaldehyde dimethyl was used in preparation of chitosan- dendrimer hybrids having various functional groups such as carboxyl, ester and poly(ethylene glycol). It was used in an synthesis of a bicyclic proline analog from L-ascorbic acid and in 3-component reaction catalyzed by MgClO4 leading to α-aminophosphonates.
General Description
Aminoacetaldehyde dimethyl acetal reacts with sulfone, followed by hydrolysis and reductive amination by adding desired piperazine derivative to yield piperazine derivatives of 2-furanyl[1,2,4]triazolo[1,5-a][1,3,5]triazine.
Purification Methods
Dry the acetal over KOH pellets and distil it through a 30cm vacuum jacketed Vigreux column (p 11). [Lawson J Am Chem Soc 75 3398 1953, Erickson et al. J Am Chem Soc 77 6640 1955, Beilstein 4 IV 1918.]
Aminoacetaldehyde dimethyl acetal Preparation Products And Raw materials
Preparation Products
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Aminoacetaldehyde dimethyl acetal(22483-09-6)Related Product Information
- ETHANE
- Dimethoxymethane
- 1,2-Dimethoxyethane
- Acetylacetaldehyde dimethyl acetal
- 4-Chlorobutanal dimethyl acetal
- Methylglyoxal 1,1-dimethyl acetal
- 2-METHOXYETHYLAMINE
- Bromoacetaldehyde diethyl acetal
- Bromoacetaldehyde dimethyl acetal
- Dimethyldimethoxysilane
- Dimethyl fumarate
- Dimethyl carbonate
- Dimethyl sulfoxide
- Chloroacetaldehyde diethyl acetal
- Chloroacetaldehyde dimethyl acetal
- Dacthal
- Acetal
- Triethylamine