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Bromoacetaldehyde diethyl acetal

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Bromoacetaldehyde diethyl acetal Basic information

Product Name:
Bromoacetaldehyde diethyl acetal
Synonyms:
  • 2,2-DIETHOXYETHYL BROMIDE
  • 1,1-DIETHOXY-2-BROMOETHANE
  • BADEA
  • BROMO ACETYL DIACETAL
  • BROMOACETAL
  • BROMOACETALDEHYDE DIETHYL ACETAL
  • 2-BROMO-1,1-DIETHOXYETHANE
  • 1-Bromo-2,2-diethoxyethane
CAS:
2032-35-1
MF:
C6H13BrO2
MW:
197.07
EINECS:
217-989-1
Product Categories:
  • Acetals/Ketals/Ortho Esters
  • Building Blocks
  • Pharmaceutical Intermediates
  • Chemical Synthesis
  • Organic Building Blocks
  • Oxygen Compounds
  • Aromatic Aldehydes & Derivatives (substituted)
  • Aliphatics
  • Miscellaneous Reagents
Mol File:
2032-35-1.mol
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Bromoacetaldehyde diethyl acetal Chemical Properties

Boiling point:
66-67 °C18 mm Hg(lit.)
Density 
1.31 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.439(lit.)
Flash point:
125 °F
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Oil
color 
Clear Colourless
Specific Gravity
1.310
Water Solubility 
immiscible
Sensitive 
Moisture Sensitive
BRN 
635754
InChIKey
LILXDMFJXYAKMK-UHFFFAOYSA-N
CAS DataBase Reference
2032-35-1(CAS DataBase Reference)
NIST Chemistry Reference
Ethane, 2-bromo-1,1-diethoxy-(2032-35-1)
EPA Substance Registry System
Ethane, 2-bromo-1,1-diethoxy- (2032-35-1)
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Safety Information

Hazard Codes 
Xi,T
Risk Statements 
10-36-36/38-23-22
Safety Statements 
16-26-45-38-37/39-28A-36/37
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
8-9-21
Hazard Note 
Toxic/Irritant
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29110000

MSDS

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Bromoacetaldehyde diethyl acetal Usage And Synthesis

Chemical Properties

Colorless to light yellow liqui

Uses

Synthetic building block1,2

Uses

Bromoacetaldehyde diethyl acetal, is used as a synthetic building block. It is mainly used for synthesis of antibiotics such as erythromycin and cephalosporins and to other drugs. It also can be used as pharmaceutical intermediates. Besides, this chemical can be used to pruduce drugs such as methylthio imidazole, chlorpheniramine and others for thyroid. It also acts as a Useful intermediate for the preparation of other ?-heterosubstituted acetaldehyde acetals.

Preparation

To a flask containing 118.0 gm (1.0 mole) of diethyl acetal and 55 gm (0.55 mole) of calcium carbonate is dropwise added 55 ml (1.0 mole) of bromine over a 30-45 min period while keeping the reaction temperature at 5°-10°C. The reaction mixture is allowed to stand 24 hr, steam is introduced to dissolve the salts, the oil separated, dried over potassium carbonate, and distilled to afford 61-83 gm (31-42%), b.p. 167°-170°C. The product is further purified by shaking with potassium carbonate and distilling it under reduced pressure, b.p. 48°-49°C (3 mm Hg). The pure acetal is unstable and becomes colored in a few hours and black after several days. However, the crude acetal boiling at 167°-170°C is stable for several months.

General Description

May darken in storage

Bromoacetaldehyde diethyl acetalSupplier

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