Bromoacetaldehyde diethyl acetal Chemical Properties

Boiling point:

66-67 °C18 mm Hg(lit.)

Density 

1.31 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.439(lit.)

Flash point:

125 °F

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Oil

color 

Clear Colourless

Specific Gravity

1.310

Water Solubility 

immiscible

Sensitive 

Moisture Sensitive

BRN 

635754

InChIKey

LILXDMFJXYAKMK-UHFFFAOYSA-N

CAS DataBase Reference

2032-35-1(CAS DataBase Reference)

NIST Chemistry Reference

Ethane, 2-bromo-1,1-diethoxy-(2032-35-1)

EPA Substance Registry System

Ethane, 2-bromo-1,1-diethoxy- (2032-35-1)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

10-36-36/38-23-22

Safety Statements 

16-26-45-38-37/39-28A-36/37

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

F 

8-9-21

Hazard Note 

Toxic/Irritant

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29110000

MSDS

• Language:English Provider:2-Bromo-1,1-diethoxyethane
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Bromoacetaldehyde diethyl acetal Usage And Synthesis

Chemical Properties

Colorless to light yellow liqui

Uses

Synthetic building block1,2

Uses

Bromoacetaldehyde diethyl acetal, is used as a synthetic building block. It is mainly used for synthesis of antibiotics such as erythromycin and cephalosporins and to other drugs. It also can be used as pharmaceutical intermediates. Besides, this chemical can be used to pruduce drugs such as methylthio imidazole, chlorpheniramine and others for thyroid. It also acts as a Useful intermediate for the preparation of other ?-heterosubstituted acetaldehyde acetals.

Preparation

To a flask containing 118.0 gm (1.0 mole) of diethyl acetal and 55 gm (0.55 mole) of calcium carbonate is dropwise added 55 ml (1.0 mole) of bromine over a 30-45 min period while keeping the reaction temperature at 5°-10°C. The reaction mixture is allowed to stand 24 hr, steam is introduced to dissolve the salts, the oil separated, dried over potassium carbonate, and distilled to afford 61-83 gm (31-42%), b.p. 167°-170°C. The product is further purified by shaking with potassium carbonate and distilling it under reduced pressure, b.p. 48°-49°C (3 mm Hg). The pure acetal is unstable and becomes colored in a few hours and black after several days. However, the crude acetal boiling at 167°-170°C is stable for several months.

General Description

May darken in storage

Bromoacetaldehyde diethyl acetal(2032-35-1)Related Product Information

• BROMOACETALDEHYDE DIETHYL ACETAL(2-BROMIDE-1,1-DIETHOXYETHANE)
• Acrolein diethyl acetal
• DIETHOXYMETHANE
• 3,3-Diethoxypropionitrile
• Diethoxymethyl acetate
• Ethoxyquin
• Aminoacetaldehyde dimethyl acetal
• Chloroacetaldehyde diethyl acetal
• 2-Bromomethyl-1,3-dioxolane
• Acetal
• Diethyl phthalate
• 4,4-Diethoxybutylamine
• 2,2-Diethoxyethylamine
• Diethyl malonate
• 1,1-Dimethoxyethane
• 2-Bromoethanol
• 2,2,2-Tribromoethanol
• Decabromodiphenyl Ethane