3,6-DIOXAOCTANEDIOIC ACID Chemical Properties

Melting point:

68-71℃

Boiling point:

429.2±25.0 °C(Predicted)

Density 

1.375

vapor pressure 

0Pa at 20℃

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

3.09±0.10(Predicted)

form 

solid

color 

White to off-white

LogP

-2.29 at 25℃

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45-27-22

RIDADR 

3261

HazardClass 

8

PackingGroup 

III

HS Code 

2917198090

3,6-DIOXAOCTANEDIOIC ACID Usage And Synthesis

Uses

3,6-Dioxaoctanedioic Acid (cas# 23243-68-7) is a useful research chemical.

Description

PEG2-(CH2CO2H)2 is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

3,6-Dioxaoctanedioic Acid is a useful reagent for the preparation of degradation agents for cyclin dependent kinase.

Uses

3,6-Dioxaoctanedioic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Flammability and Explosibility

Not classified

Synthesis

To 15 ml (0.33 mol) of nitric acid was added at 45??C while stirring 1 g of diethylene glycol from the overall amount of 5.9 g (0.06 mol), and the mixture was heated to 65??C. After the end of nitrogen oxides evolution and cooling the mixture to 45-50??C another portion of diethylene glycol was added. Overall time of the reagent addition to the reaction mixture was 1 h. The mixture was kept at 45??C for 40 min and then it was heated at 80??C for 30 min. The solvent was removed in a vacuum at 70??C, the residue was dried by azeotropic distillation with benzene using Dean-Stark trap, then the product was fi ltered off and recrystallized from acetone-benzene mixture. 3,6-Dioxaoctanedioic acid (VIII) was similarly obtained. Yield 7.3 g (89%), colorless crystals. Rf 0.20 (E), mp 76-77??C (mp 75-76??C [13]). IR spectrum, |í, cm-1: 3167 (OH), 2914 (CH), 1733 (C=O acid), 1410, 1229 (C-O), 1121 (C-O). Mass spectrum, m/z (Irel, %): 178.5 [M]+ (76), 200.9 (55), 216.8 (46).

3,6-DIOXAOCTANEDIOIC ACID(23243-68-7)Related Product Information

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