5-Methyl-7-methoxyisoflavone Chemical Properties

Melting point:

116-120 °C

Boiling point:

349.5°C (rough estimate)

Density 

1.2327 (rough estimate)

refractive index 

1.4500 (estimate)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly, Sonicated)

form 

Solid

color 

White to Off-White

LogP

4.242 (est)

CAS DataBase Reference

82517-12-2(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

HS Code 

29145000

MSDS

• Language:English Provider:ACROS

5-Methyl-7-methoxyisoflavone Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

5-Methyl-7-methoxyisoflavone is an orally active anti-oxidant with remyelinating activity. 5-Methyl-7-methoxyisoflavone inhibits the enzyme aromatase, interfering with the normal metabolic pathways of testosterone. 5-Methyl-7-methoxyisoflavone is a non-steroidal anabolic isoflavone, used as a anabolic agent. 5-Methyl-7-methoxyisoflavone shows better potency increasing muscle mass and endurance than Ipriflavone (HY-N0094). 5-Methyl-7-methoxyisoflavone can be used for fat loss besides the maintenance of low cholesterol level and strengthen bones. 5-Methyl-7-methoxyisoflavone is the inhibitor for NF-κB[1][2][3][4].

References

[1] Ningbo Gong, et al. Concomitant polymorphs of methoxyflavone (5-methyl-7-methoxyflavone). RSC Adv., 2016, 6, 38709-38715.
[2] Agresti C, et al. Oxidative status in multiple sclerosis and off-targets of antioxidants: the case of edaravone[J]. Current Medicinal Chemistry, 2020, 27(13): 2095-2105. DOI:10.2174/0929867326666190124122752
[3] Iannone M, et al. An investigation on the metabolic pathways of synthetic isoflavones by gas chromatography coupled to high accuracy mass spectrometry. Rapid Commun Mass Spectrom. 2019 Oct 15;33(19):1485-1493. DOI:10.1002/rcm.8490
[4] Lecompte Y, et al. UPLC-ESI-Q-TOF-MS(E) identification of urinary metabolites of the emerging sport nutrition supplement methoxyisoflavone in human subjects. J Pharm Biomed Anal. 2014 Aug 5;96:127-34. DOI:10.1016/j.jpba.2014.03.031
[5] Lee S, et al., Isoflavone derivatives inhibit NF-κB-dependent transcriptional activity. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6277-81. DOI:10.1016/j.bmcl.2010.08.089
[6] Hyun J, et al., Isoflavones inhibit the clonogenicity of human colon cancer cells. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2664-9. DOI:10.1016/j.bmcl.2012.03.027

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