Thalicarpine Chemical Properties

Melting point:

160-161°

alpha 

D25 +133° (c = 0.83 in methanol); D25 +89° (c = 0.88 in chloroform)

Boiling point:

701.43°C (rough estimate)

Density 

1.1544 (rough estimate)

refractive index 

1.4670 (estimate)

pka

7.62±0.40(Predicted)

Thalicarpine Usage And Synthesis

Description

A complex alkaloid, thaliblastine occurs in Thalictrum minus elatum and has been assigned the structure given on the basis of chemical and spectroscopic investigations. The alkaloid has marked antitumour activity but rapid administration of the base causes brachycardia, hypotension and inhibition of respiration in laboratory animals. Slow intravenous injection, however, produces none of these effects. Thaliblastine is cytotoxic to HEF and Sa9 cells in vitro.

Definition

ChEBI: Thalicarpine is a member of isoquinolines and a bisbenzylisoquinoline alkaloid.

References

Todorov, Damyanova,Dokl. Bolg. Akad. Nauk., 28, 709 (1975)

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