8-O-acetyl shanzhiside methyl ester Chemical Properties

Boiling point:

634.2±55.0 °C(Predicted)

Density 

1.52

solubility 

Soluble in methan

form 

powder

pka

12.80±0.70(Predicted)

color 

White

Safety Information

Safety Statements 

24/25

HS Code 

29389090

8-O-acetyl shanzhiside methyl ester Usage And Synthesis

Chemical Properties

Off-white crystalline powder, easily soluble in methanol and ethanol, derived from unique flavor.

Uses

8-O-acetyl shanzhiside methyl ester can be used for content determination, identification and pharmacological experiments, etc. It can activate congestion, relieve pain and stop bleeding.

in vitro

Treatment of SH-SY5Y cells with 8-O-Acetyl shanzhiside methyl ester blocks TNF-α-induced nuclear transcription factor κB (NF-κB) activation and decreases high-mobility group box-1 ( HMGB-1) expression . Treatment of H9c2 cells with it 9 μM blocks TNF-α-induced NF-κB phosphorylation by blocking High-mobility group box1 (HMGB1) expression.

in vivo

8-O-Acetyl shanzhiside methyl ester significantly promotes angiogenesis in the ischaemic brain and improves functional outcome after stroke. It also significantly increases vascularization compared with vehicle treatment. 8-O-Acetyl shanzhiside methyl ester significantly shortens capillary blood clotting time and reduces blood loss volume, but does not influence mice activated partial thromboplastin time , prothrombin time or thrombin time.

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