HYOCHOLIC ACID
HYOCHOLIC ACID Basic information
- Product Name:
- HYOCHOLIC ACID
- Synonyms:
-
- LAMBDA-MURICHOLIC ACID
- HYOCHOLIC ACID
- GAMMA MURICHOLIC
- 3,6,7-trihydroxy-,(3alpha,5beta,6alpha,7alpha)-cholan-24-oicaci
- 3-ALPHA,6-ALPHA,7-ALPHA-TRIHYDROXY-5-BETA-CHOLAN-24-OIC ACID
- 3A,6A-7A-TRIHYDROXY-5B-CHOLAN-24-OIC ACID
- 5B-CHOLAN-24-OIC ACID-3A,6A,7A-TRIOL
- 5-BETA-CHOLAN-24-OIC ACID-3-ALPHA,6-ALPHA,7-ALPHA-TRIOL
- CAS:
- 547-75-1
- MF:
- C24H40O5
- MW:
- 408.57
- EINECS:
- 208-935-8
- Mol File:
- 547-75-1.mol
HYOCHOLIC ACID Chemical Properties
- Melting point:
- 162 °C
- Boiling point:
- 565.7±40.0 °C(Predicted)
- Density
- 1.184±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Ethanol (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 4.76±0.10(Predicted)
- color
- Light Brown to Brown
- optical activity
- +5.525
HYOCHOLIC ACID Usage And Synthesis
Uses
3α,6α,7α-Trihydroxy-5β-cholanic Acid is one of the bile acids categorizes under muricholic acid, a group of bile acids found in human urine due to its additional hydroxyl groups. The synthesis of 3α,6α,7α-Trihydroxy-5β-cholanic Acid was shown to be promoted due to overexpression of cholesterol 7α-hydroxylase enzyme.
Definition
ChEBI: A trihydroxy-5beta-cholanic acid in which the three hydroxy substituents are located at the 3alpha-, 6alpha- and 7alpha-positions.
Biological Activity
Hyocholic acid levels are elevated in plasma and urine samples of patients with cholestatic liver disease and in hepatic cirrhosis.
in vivo
Hyocholic Acid (20 mg/kg, p.o.) suppresses BA depletion-induced blood glucose increase in pigs[3].
Hyocholic Acid (100 mg/kg/day, p.o.) improves serum fasting GLP-1 secretion and glucose homeostasis in diabetic mouse models[3].
| Animal Model: | BA depletion pigs[3] |
| Dosage: | 20 mg/kg |
| Administration: | Oral administration (p.o.) |
| Result: | Attenuated the increased blood glucose levels corresponding with GLP-1 decrease. |
| Animal Model: | db/db model, and the high-fat diet and streptozotocin (HFD+STZ) induced diabetic model[3] |
| Dosage: | 100 mg/kg/day |
| Administration: | Oral administration (p.o.) |
| Result: | Improved oral glucose tolerances shown by lower glucose levels. Increased circulating active GLP-1 levels and fasting insulin levels. |
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HYOCHOLIC ACID(547-75-1)Related Product Information
- Baicalin
- 12-HYDROXYDODECANOIC ACID
- CHOLANIC ACID
- HYOCHOLIC ACID
- Hyodeoxycholic acid
- 9,10-DIHYDROXYSTEARIC ACID
- Ursodeoxycholic acid
- 16-HYDROXYHEXADECANOIC ACID
- LITHOCHOLIC ACID
- 2,7-Decahydronaphthalenediol
- 12-HYDROXYSTEARIC ACID
- 5BETA-CHOLANIC ACID
- 5beta-Cholan-3alpha,7alpha,24-triol
- CIS,TRANS,TRANS-3,5-DIMETHYLCYCLOHEXANOL
- ERYTHRO-5,6-DODECANEDIOL
- HYOCHOLIC ACID METHYL ESTER
- 5-BETA-CHOLAN-24-OL
- Hyodeoxycholic acid Impurity 9