(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE Chemical Properties

Boiling point:

457.4±45.0 °C(Predicted)

Density 

1.37

storage temp. 

2-8°C

pka

-2.18±0.40(Predicted)

InChI

InChI=1S/C21H19F6NO3/c1-13(15-9-16(20(22,23)24)11-17(10-15)21(25,26)27)31-19-18(29)28(7-8-30-19)12-14-5-3-2-4-6-14/h2-6,9-11,13,19H,7-8,12H2,1H3/t13-,19-/m1/s1

InChIKey

KVPJNHLVRGUYGQ-BFUOFWGJSA-N

SMILES

N1(CC2=CC=CC=C2)CCO[C@H](O[C@@H](C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C)C1=O

(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE Usage And Synthesis

Uses

(2R)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-4-(phenylmethyl)-3-morpholinone, is the key 3-(4-Fluorophenyl)morpholine moiety used in the synthesis of NK1 receptor antagonist Aprepitant (A729800).

(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE(287930-75-0)Related Product Information

• (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine
• TRANS-4-AMINOCROTONIC ACID
• 7-Fluoro-4-quinazolone
• 7-Fluoro-6-nitro-4-hydroxyquinazoline
• Afatinib impurity 45
• Benzyl dihydrogen phosphate
• (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine
• (2R,3R)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride
• Aprepitant
• (2R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-5,6-dihydro-2H-1,4-oxazine
• Aprepitant Impurity 17
• Aprepitant Impurity 6
• Aprepitant
• Fosaprepitant Benzyl Ester
• (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine hydrochloride
• (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine
• (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride
• (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate