Basic information Safety Supplier Related

(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE

Basic information Safety Supplier Related

(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE Basic information

Product Name:
(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE
Synonyms:
  • (2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE
  • (R)-4-benzyl-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)Morpholin-3-one
  • (2R)-4-Benzyl-2-{(1R)-1-[3,5-Bis(trifluoromethyl)
  • Aprepitant Impurity 29
  • Aprepitant iMpurity 39
  • (R)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-4-benzylMorpholin-3-one
  • (2R)-4-benzyl-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)Morpholin-3-one
  • (2R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-4-(phenylMethyl)-3-Morpholinone
CAS:
287930-75-0
MF:
C21H19F6NO3
MW:
447.37
EINECS:
1312995-182-4
Mol File:
287930-75-0.mol
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(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE Chemical Properties

Boiling point:
457.4±45.0 °C(Predicted)
Density 
1.37
storage temp. 
2-8°C
pka
-2.18±0.40(Predicted)
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(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE Usage And Synthesis

Uses

(2R)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-4-(phenylmethyl)-3-morpholinone, is the key 3-(4-Fluorophenyl)morpholine moiety used in the synthesis of NK1 receptor antagonist Aprepitant (A729800).

(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONESupplier

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