3-Amino-5-bromo-2-chloropyridine Chemical Properties

Melting point:

129-132℃

Boiling point:

296.8±35.0 °C(Predicted)

Density 

1.834±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to crystal

pka

0.03±0.10(Predicted)

color 

White to Orange to Green

λmax

314nm(EtOH)(lit.)

InChI

InChI=1S/C5H4BrClN2/c6-3-1-4(8)5(7)9-2-3/h1-2H,8H2

InChIKey

ZSEZSALOLWCCGT-UHFFFAOYSA-N

SMILES

C1(Cl)=NC=C(Br)C=C1N

CAS DataBase Reference

588729-99-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

25-37/38-41-22

Safety Statements 

26-39-45

RIDADR 

2811

WGK Germany 

3

HazardClass 

IRRITANT

PackingGroup 

Ⅲ

HS Code 

29333990

3-Amino-5-bromo-2-chloropyridine Usage And Synthesis

Chemical Properties

Colorless solid

Uses

3-Amino-5-bromo-2-chloropyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

Step 1: 2-Chloro-3-nitro-5-bromopyridine (2.38 g, 10 mmol) was dissolved in methanol (50 mL) and Raney nickel (0.5 g) was added. The reaction mixture was stirred overnight under hydrogen atmosphere. Upon completion of the reaction, the Raney nickel was removed by filtration and the filtrate was concentrated to afford 2-chloro-3-amino-5-bromopyridine (2.08 g, 100% yield), which could be used in subsequent reactions without further purification. Mass spectrum (ESI) m/z: 208.9 [M + 1].

References

[1] Patent: EP2952510, 2015, A1. Location in patent: Paragraph 0146
[2] Patent: WO2008/157191, 2008, A2. Location in patent: Page/Page column 75
[3] Patent: WO2008/150827, 2008, A1. Location in patent: Page/Page column 69
[4] Journal of Heterocyclic Chemistry, 2003, vol. 40, # 2, p. 261 - 268
[5] Patent: US2012/238587, 2012, A1. Location in patent: Page/Page column 17

3-Amino-5-bromo-2-chloropyridine(588729-99-1)Related Product Information

• 3-Amino-5-bromopyridine
• 2-Amino-5-bromopyridine
• 3-Bromo-2-chloropyridine
• 4-Dimethylaminopyridine
• 3-Aminopyridine
• Triallylamine
• 1-Hexadecylpyridinium bromide
• 2-Chloro-3-pyridinamine
• Bis(2-ethylhexyl)amine
• ALTRENOGEST
• Dibenzylamine
• 6-Aminocaproic acid
• Glycine
• 2-Aminopyridine
• 3-Aminophenol
• 5-Bromo-2-chloro-3-nitropyridine
• Tris(hydroxymethyl)aminomethane
• 6-BROMO-2-CHLOROPYRIDIN-3-AMINE