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5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

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5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride Basic information

Product Name:
5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Synonyms:
  • 1H-Inden-2-aMine,5,6-diethyl-2,3-dihydro-,hydrochloride (1:1)
  • 5,6-Diethyl-2,3-dihydro-1H-inden-2-aMino Hydrochloride
  • 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride 312753-53-0
  • 1H-Inden-2-amine,5,6-diethyl-2,3-dihydro-, hydrochloride
  • 5-ethyl-2,3-dihydro-1H-inden-2-amine
  • 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
  • 5,6-diethyl-2,3-dihydro-1H-inden-2-amine
  • Indacaterol Intermediate 1
CAS:
312753-53-0
MF:
C13H20ClN
MW:
225.76
EINECS:
691-331-5
Product Categories:
  • Intermediate of Indacaterol
Mol File:
312753-53-0.mol
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5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride Chemical Properties

Melting point:
>250 ºC
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White
CAS DataBase Reference
312753-53-0(CAS DataBase Reference)
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5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride Usage And Synthesis

Uses

5,6-Diethyl-2,3-dihydro-1H-inden-2-amine Hydrochloride acts as a reagent in the synthetic preparation of quinolinone compounds and it’s formulations in combination with corticosteroids for treatment of airway disorder.

Uses

5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis


Preparation 4-5,6-Diethyl-indan-2-ylamine Hydrochloride 5,6-Diethyl-3-oxime-1H-indene-1,2(3H)-dione (4.5 g) is added to a mixture of acetic acid (150 mL), and concentrated sulphuric acid (4.5 mL). Pd/C5% (1.5 g) is added, the reaction mixture degassed with nitrogen, and hydrogenated for 5 hours. The catalyst is then removed by filtration, the pH brought to pH 10 with 4M NaOH, and the solution extracted with chloroform. The organic phase is dried with magnesium sulphate, and the solvent removed in vacuo. The residue is redisolved in a minimum amount of ether, and HCl saturated ether added. The white precipitate is filtered and dried to yield the HCl salt of 5,6-diethyl-indan-2-ylamine, a compound of formula XVII where R3, R4 and R7 are H, R5 and R6 are each CH3CH2-, R30 is hydrogen and n is 1. 5,6-Diethyl-indan-2-ylamine Hydrochloride.

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